Computational fluid dynamics analysis of thrombosis potential in left ventricular assist device drainage cannulae

Katharine H. Fraser, Tao Zhang, M Ertan Taskin, Bartley P. Griffith, Zhongjun J. Wu

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Cannulation is necessary when blood is removed from the body, for example in hemodialysis, cardiopulmonary bypass, blood oxygenators, and ventricular assist devices. Artificial blood contacting surfaces are prone to thrombosis, especially in the presence of stagnant or recirculating flow. In this work, computational fluid dynamics was used to investigate the blood flow fields in three clinically available cannulae (Medtronic DLP 12, 16, and 24 F), used as drainage for pediatric circulatory support and to calculate parameters that may be indicative of thrombosis potential. The results show that using the 24 F cannula below flow rates of about 0.75 L/min produces hemodynamic conditions, which may increase the risk of blood clotting within the cannula. No reasons are indicated for not using the 12 or 16 F cannulae with flow rates between 0.25 and 3.0 L/min.
Original languageEnglish
Pages (from-to)157-163
JournalASAIO journal (American Society for Artificial Internal Organs: 1992)
Volume56
Issue number3
DOIs
Publication statusPublished - May 2010

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