Compound Class 18: 1,1-Diacyloxy Compounds

Laura H. Smith; Susannah C. Coote; David J. Procter

doi:10.1055/sos-SD-129-00201

Compound Class 18: 1,1-Diacyloxy Compounds

Laura H. Smith, Susannah C. Coote, David J. Procter

Department of Chemistry

Research output: Chapter or section in a book/report/conference proceeding › Chapter or section

Abstract

1,1-Diacyloxy compounds can be accessed from a variety of starting materials including aldehydes, ketones, and O/O, O/Hal, and Hal/Hal acetals under a variety of reaction conditions. This product class encompasses Meldrum’s acid, several natural products, and acyloxy ester prodrugs; in addition, acyl acetals are useful protecting groups for aldehydes and can be cleaved orthogonally to alkyl acetals.

Original language	English
Title of host publication	Science of Synthesis
Editors	K. Ishihara, D. J. Proctor, E. Schaumann
Place of Publication	Stuttgart, Germany
Publisher	Georg Thieme Verlag
Pages	475-496
Volume	29
ISBN (Electronic)	9783131843814
ISBN (Print)	9783131541611
DOIs	https://doi.org/10.1055/sos-SD-129-00201
Publication status	Published - 31 Mar 2010

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abstract = "1,1-Diacyloxy compounds can be accessed from a variety of starting materials including aldehydes, ketones, and O/O, O/Hal, and Hal/Hal acetals under a variety of reaction conditions. This product class encompasses Meldrum{\textquoteright}s acid, several natural products, and acyloxy ester prodrugs; in addition, acyl acetals are useful protecting groups for aldehydes and can be cleaved orthogonally to alkyl acetals.",

author = "Smith, {Laura H.} and Coote, {Susannah C.} and Procter, {David J.}",

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AU - Coote, Susannah C.

AU - Procter, David J.

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Y1 - 2010/3/31

N2 - 1,1-Diacyloxy compounds can be accessed from a variety of starting materials including aldehydes, ketones, and O/O, O/Hal, and Hal/Hal acetals under a variety of reaction conditions. This product class encompasses Meldrum’s acid, several natural products, and acyloxy ester prodrugs; in addition, acyl acetals are useful protecting groups for aldehydes and can be cleaved orthogonally to alkyl acetals.

AB - 1,1-Diacyloxy compounds can be accessed from a variety of starting materials including aldehydes, ketones, and O/O, O/Hal, and Hal/Hal acetals under a variety of reaction conditions. This product class encompasses Meldrum’s acid, several natural products, and acyloxy ester prodrugs; in addition, acyl acetals are useful protecting groups for aldehydes and can be cleaved orthogonally to alkyl acetals.

U2 - 10.1055/sos-SD-129-00201

DO - 10.1055/sos-SD-129-00201

M3 - Chapter or section

SN - 9783131541611

VL - 29

SP - 475

EP - 496

BT - Science of Synthesis

A2 - Ishihara, K.

A2 - Proctor, D. J.

A2 - Schaumann, E.

PB - Georg Thieme Verlag

CY - Stuttgart, Germany

ER -

Compound Class 18: 1,1-Diacyloxy Compounds

Abstract

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