Abstract
Complex regional pain syndrome (CRPS) is a rare pain disorder that usually occurs in a limb after trauma. The features of this disorder include severe pain and sensory, autonomic, motor, and trophic abnormalities. Research from the past decade has offered new insights into CRPS epidemiology, pathophysiology, diagnosis, and treatment. Early identification of individuals at high risk of CRPS is improving, with several risk factors established and some others identified in prospective studies during the past 5 years. Better understanding of the pathophysiological mechanisms of CRPS has led to its classification as a chronic primary pain disorder, and subtypes of CRPS have been updated. Procedures for diagnosis have also been clarified. Although effective treatment of CRPS remains a challenge, evidence-based integrated management approaches provide new opportunities to improve patient care. Further advances in diagnosis and treatment of CRPS will require coordinated, international multicentre initiatives.
| Original language | English |
|---|---|
| Pages (from-to) | 522-533 |
| Number of pages | 12 |
| Journal | The Lancet Neurology |
| Volume | 23 |
| Issue number | 5 |
| Early online date | 15 Apr 2024 |
| DOIs | |
| Publication status | Published - 31 May 2024 |
Funding
MCF is supported by an Australian Government Research Training Program scholarship and the Neuroscience Research Australia PhD Pearl supplementary scholarship; has received research grants from ERA-NET NEURON for research related to CRPS and neuropathic pain; and is a committee member of the IASP special interest group for CRPS. NEO has received funding from the National Health and Medical Research Council of Australia and ERA-NET NEURON for research related to CRPS. CS is funded by the German Research Foundation for the Clinical Research Group KFO5001 ResolvePAIN and has received funding from Deutsche Forschungsgemeinschaft and Bundesministerium für Bildung und Forschung. AG has received funding from the UK Medical Research Council, Pain Relief Foundation Liverpool, and Versus Arthritis; has been a consultant for UCB and Novartis; is Chair of the Scientific Committee of the British Pain Society, past Chair of the IASP special interest group for CRPS, and Chair of the European Pain Federation CRPS task force; and is a member of the scientific committee for the Pain Relief Foundation. JHB is co-Chair of the IASP special interest group for CRPS; has received fees for speaking about CRPS paid by Theoria Congresos, at a conference organised by Hospital Intermutual de Levante; and has received research funding from the Reflex Sympathetic Dystrophy Syndrome Association, the Netherlands Organisation for Scientific Research, and the Experimental Psychological Society. AGC, GLM, and JHM receive salary support from investigator grants from the National Health and Medical Research Council of Australia. GLM receives royalties for a book about a specific rehabilitation approach to CRPS that is mentioned in this Review; is an unpaid board member of the consumer advocacy body Pain Australia, and is an unpaid Chief Executive Officer of the non-profit community outreach initiative Pain Revolution. GLM and JHM have received funding from the National Health and Medical Research Council of Australia for research on CRPS.
ASJC Scopus subject areas
- Clinical Neurology