Competition between transposable elements and mutator genes in bacteria

T. Feher, B. Bogos, O. Mehi, G. Fekete, B. Csorgo, K. Kovacs, G. Posfai, B. Papp, L. D. Hurst, C. Pal

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Although both genotypes with elevated mutation rate (mutators) and mobilization of insertion sequence (IS) elements have substantial impact on genome diversification, their potential interactions are unknown. Moreover, the evolutionary forces driving gradual accumulation of these elements are unclear: Do these elements spread in an initially transposon-free bacterial genome as they enable rapid adaptive evolution? To address these issues, we inserted an active IS1 element into a reduced Escherichia coli genome devoid of all other mobile DNA. Evolutionary laboratory experiments revealed that IS elements increase mutational supply and occasionally generate variants with especially large phenotypic effects. However, their impact on adaptive evolution is small compared with mismatch repair mutator alleles, and hence, the latter impede the spread of IS-carrying strains. Given their ubiquity in natural populations, such mutator alleles could limit early phase of IS element evolution in a new bacterial host. More generally, our work demonstrates the existence of an evolutionary conflict between mutation-promoting mechanisms.
Original languageEnglish
Pages (from-to)3153-3159
JournalMolecular Biology and Evolution
Volume29
Issue number10
Early online date23 Apr 2012
DOIs
Publication statusPublished - 1 Oct 2012

Fingerprint

DNA Transposable Elements
Mutation Rate
transposons
mutation
Bacteria
bacterium
genome
gene
bacteria
Alleles
Genome
Genes
Bacterial Genomes
allele
DNA Mismatch Repair
genes
Insertional Mutagenesis
alleles
Genotype
Escherichia coli

Cite this

Feher, T., Bogos, B., Mehi, O., Fekete, G., Csorgo, B., Kovacs, K., ... Pal, C. (2012). Competition between transposable elements and mutator genes in bacteria. Molecular Biology and Evolution, 29(10), 3153-3159. https://doi.org/10.1093/molbev/mss122

Competition between transposable elements and mutator genes in bacteria. / Feher, T.; Bogos, B.; Mehi, O.; Fekete, G.; Csorgo, B.; Kovacs, K.; Posfai, G.; Papp, B.; Hurst, L. D.; Pal, C.

In: Molecular Biology and Evolution, Vol. 29, No. 10, 01.10.2012, p. 3153-3159.

Research output: Contribution to journalArticle

Feher, T, Bogos, B, Mehi, O, Fekete, G, Csorgo, B, Kovacs, K, Posfai, G, Papp, B, Hurst, LD & Pal, C 2012, 'Competition between transposable elements and mutator genes in bacteria', Molecular Biology and Evolution, vol. 29, no. 10, pp. 3153-3159. https://doi.org/10.1093/molbev/mss122
Feher T, Bogos B, Mehi O, Fekete G, Csorgo B, Kovacs K et al. Competition between transposable elements and mutator genes in bacteria. Molecular Biology and Evolution. 2012 Oct 1;29(10):3153-3159. https://doi.org/10.1093/molbev/mss122
Feher, T. ; Bogos, B. ; Mehi, O. ; Fekete, G. ; Csorgo, B. ; Kovacs, K. ; Posfai, G. ; Papp, B. ; Hurst, L. D. ; Pal, C. / Competition between transposable elements and mutator genes in bacteria. In: Molecular Biology and Evolution. 2012 ; Vol. 29, No. 10. pp. 3153-3159.
@article{31f6866898a84d6f9868eced92a9eea9,
title = "Competition between transposable elements and mutator genes in bacteria",
abstract = "Although both genotypes with elevated mutation rate (mutators) and mobilization of insertion sequence (IS) elements have substantial impact on genome diversification, their potential interactions are unknown. Moreover, the evolutionary forces driving gradual accumulation of these elements are unclear: Do these elements spread in an initially transposon-free bacterial genome as they enable rapid adaptive evolution? To address these issues, we inserted an active IS1 element into a reduced Escherichia coli genome devoid of all other mobile DNA. Evolutionary laboratory experiments revealed that IS elements increase mutational supply and occasionally generate variants with especially large phenotypic effects. However, their impact on adaptive evolution is small compared with mismatch repair mutator alleles, and hence, the latter impede the spread of IS-carrying strains. Given their ubiquity in natural populations, such mutator alleles could limit early phase of IS element evolution in a new bacterial host. More generally, our work demonstrates the existence of an evolutionary conflict between mutation-promoting mechanisms.",
author = "T. Feher and B. Bogos and O. Mehi and G. Fekete and B. Csorgo and K. Kovacs and G. Posfai and B. Papp and Hurst, {L. D.} and C. Pal",
year = "2012",
month = "10",
day = "1",
doi = "10.1093/molbev/mss122",
language = "English",
volume = "29",
pages = "3153--3159",
journal = "Molecular Biology and Evolution",
issn = "0737-4038",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Competition between transposable elements and mutator genes in bacteria

AU - Feher, T.

AU - Bogos, B.

AU - Mehi, O.

AU - Fekete, G.

AU - Csorgo, B.

AU - Kovacs, K.

AU - Posfai, G.

AU - Papp, B.

AU - Hurst, L. D.

AU - Pal, C.

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Although both genotypes with elevated mutation rate (mutators) and mobilization of insertion sequence (IS) elements have substantial impact on genome diversification, their potential interactions are unknown. Moreover, the evolutionary forces driving gradual accumulation of these elements are unclear: Do these elements spread in an initially transposon-free bacterial genome as they enable rapid adaptive evolution? To address these issues, we inserted an active IS1 element into a reduced Escherichia coli genome devoid of all other mobile DNA. Evolutionary laboratory experiments revealed that IS elements increase mutational supply and occasionally generate variants with especially large phenotypic effects. However, their impact on adaptive evolution is small compared with mismatch repair mutator alleles, and hence, the latter impede the spread of IS-carrying strains. Given their ubiquity in natural populations, such mutator alleles could limit early phase of IS element evolution in a new bacterial host. More generally, our work demonstrates the existence of an evolutionary conflict between mutation-promoting mechanisms.

AB - Although both genotypes with elevated mutation rate (mutators) and mobilization of insertion sequence (IS) elements have substantial impact on genome diversification, their potential interactions are unknown. Moreover, the evolutionary forces driving gradual accumulation of these elements are unclear: Do these elements spread in an initially transposon-free bacterial genome as they enable rapid adaptive evolution? To address these issues, we inserted an active IS1 element into a reduced Escherichia coli genome devoid of all other mobile DNA. Evolutionary laboratory experiments revealed that IS elements increase mutational supply and occasionally generate variants with especially large phenotypic effects. However, their impact on adaptive evolution is small compared with mismatch repair mutator alleles, and hence, the latter impede the spread of IS-carrying strains. Given their ubiquity in natural populations, such mutator alleles could limit early phase of IS element evolution in a new bacterial host. More generally, our work demonstrates the existence of an evolutionary conflict between mutation-promoting mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=84866940698&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1093/molbev/mss122

U2 - 10.1093/molbev/mss122

DO - 10.1093/molbev/mss122

M3 - Article

VL - 29

SP - 3153

EP - 3159

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 0737-4038

IS - 10

ER -