Competition and intrinsic displacement effects in overloaded weak affinity chromatography

John Hubble

Research output: Contribution to journalArticle

Abstract

A simple model is presented that describes the competitive adsorption of two components in a weak affinity adsorption system. Unlike previous models, the approach used here allows description of nonlinear isotherms operated under overloaded conditions. The results obtained suggest that, unlike std. elution protocols, significant concn. effects can be achieved in zonal operation as a result of intrinsic displacement effects, where a more strongly bound contaminant displaces a weakly bound product. [on SciFinder (R)]
Original languageEnglish
Pages (from-to)541-554
Number of pages14
JournalSeparation Science and Technology
Volume36
Issue number4
Publication statusPublished - 2001

Keywords

  • competition and intrinsic displacement effects in overloaded weak affinity chromatog.)
  • Adsorption (competitive
  • Affinity chromatography (weak
  • Preparative chromatography
  • adsorption isotherm overloaded weak affinity chromatog
  • Simulation and Modeling (competition and intrinsic displacement effects in overloaded weak affinity chromatog.)

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