Comparison of the cohesion-adhesion balance approach to colloidal probe atomic force microscopy and the measurement of Hansen partial solubility parameters by inverse gas chromatography for the prediction of dry powder inhalation performance

Matthew D. Jones, Graham Buckton

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
226 Downloads (Pure)

Abstract

The abilities of the cohesive-adhesive balance approach to atomic force microscopy (AFM) and the measurement of Hansen partial solubility parameters by inverse gas chromatography (IGC) to predict the performance of carrier-based dry powder inhaler (DPI) formulations were compared. Five model drugs (beclometasone dipropionate, budesonide, salbutamol sulphate, terbutaline sulphate and triamcinolone acetonide) and three model carriers (erythritol, α-lactose monohydrate and D-mannitol) were chosen, giving fifteen drug-carrier combinations. Comparison of the AFM and IGC interparticulate adhesion data suggested that they did not produce equivalent results. Comparison of the AFM data with the in vitro fine particle delivery of appropriate DPI formulations normalised to account for particle size differences revealed a previously observed pattern for the AFM measurements, with a slightly cohesive AFM CAB ratio being associated with the highest fine particle fraction. However, no consistent relationship between formulation performance and the IGC data was observed. The results as a whole highlight the complexity of the many interacting variables that can affect the behaviour of DPIs and suggest that the prediction of their performance from a single measurement is unlikely to be successful in every case.
Original languageEnglish
Article numberIJP-D-16-00632R1
Pages (from-to)419-430
Number of pages12
JournalInternational Journal of Pharmaceutics
Volume509
Issue number1-2
Early online date2 Jun 2016
DOIs
Publication statusPublished - 25 Jul 2016

Keywords

  • adhesion
  • atomic force microscopy
  • dry powder inhaler
  • inverse gas chromatography
  • Materials science
  • physical characterisation

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