Comparison of drug release from poly(lactide-co-glycolide) microspheres and novel fibre formulations

Christopher S J Campbell, M Begona Delgado-Charro, Olivier Camus, Semali Perera

Research output: Contribution to journalArticle

2 Citations (Scopus)
184 Downloads (Pure)

Abstract

Intraperitoneal cisplatin delivery has recently been shown to benefit ovarian cancer patients. Cisplatin-containing poly(lactide-co-glycolide) (PLGA) microspheres have been proposed for cisplatin delivery. The drug loading of cisplatin containing microspheres produced elsewhere is 3 10 %w. Similar microspheres are reported here with a mean diameter of 38.8 μm, and a drug loading of 11.7 %w, but using ethyl acetate as a safer solvent. In addition, novel formulations of cisplatin-containing solid and hollow PLGA 65:35 (lactide:glycolide) fibres were prepared and are reported here for the first time. PLGA hollow fibres were produced by phase inversion with a high drug loading of 27 %w. Mechanistic mathematical models were applied to the cisplatin release profiles to allow quantitative comparison of microsphere, solid fibre and hollow fibre formulations. The diffusion coefficient of cisplatin eluting from a typical batch of PLGA microspheres was 4.8×10 13 cm2 s-1; this low diffusivity of cisplatin in microspheres was caused by the low porosity of the polymer matrix. The diffusion coefficients of cisplatin eluting from a batch of PLGA solid fibres and hollow fibres were 6.1×10 10 and 3.3×10 10 cm2 s-1, respectively. These fibres allowed the controlled release of high doses of cisplatin over four days and may represent an improvement in slow release technology for treatment of ovarian cancer.
Original languageEnglish
Pages (from-to)1142-1153
Number of pages12
JournalJournal of Biomaterials Applications
Volume30
Issue number8
Early online date29 Nov 2015
DOIs
Publication statusPublished - 1 Mar 2016
EventA. Alsharif, Y. M. J. Chew, D. B. Lukyanov, and S. P. Perera, The influence of bore fluid concentration on porous structure in a 13X zeolite adsorbent hollow fibre for gas separation - Scientific Society for Saudi Arabia (organised by University of Birmingham) , Birmingham, UK United Kingdom
Duration: 14 Feb 201615 Feb 2016

Keywords

  • Cisplatin
  • poly(lactide-co-glycolide)
  • intraperitoneal
  • ovarian cancer
  • fibres
  • mathematical model

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