Intraperitoneal cisplatin delivery has recently been shown to benefit ovarian cancer patients. Cisplatin-containing poly(lactide-co-glycolide) (PLGA) microspheres have been proposed for cisplatin delivery. The drug loading of cisplatin containing microspheres produced elsewhere is 3 10 %w. Similar microspheres are reported here with a mean diameter of 38.8 μm, and a drug loading of 11.7 %w, but using ethyl acetate as a safer solvent. In addition, novel formulations of cisplatin-containing solid and hollow PLGA 65:35 (lactide:glycolide) fibres were prepared and are reported here for the first time. PLGA hollow fibres were produced by phase inversion with a high drug loading of 27 %w. Mechanistic mathematical models were applied to the cisplatin release profiles to allow quantitative comparison of microsphere, solid fibre and hollow fibre formulations. The diffusion coefficient of cisplatin eluting from a typical batch of PLGA microspheres was 4.8×10 13 cm2 s-1; this low diffusivity of cisplatin in microspheres was caused by the low porosity of the polymer matrix. The diffusion coefficients of cisplatin eluting from a batch of PLGA solid fibres and hollow fibres were 6.1×10 10 and 3.3×10 10 cm2 s-1, respectively. These fibres allowed the controlled release of high doses of cisplatin over four days and may represent an improvement in slow release technology for treatment of ovarian cancer.
|Number of pages||12|
|Journal||Journal of Biomaterials Applications|
|Early online date||29 Nov 2015|
|Publication status||Published - 1 Mar 2016|
|Event||A. Alsharif, Y. M. J. Chew, D. B. Lukyanov, and S. P. Perera, The influence of bore fluid concentration on porous structure in a 13X zeolite adsorbent hollow fibre for gas separation - Scientific Society for Saudi Arabia (organised by University of Birmingham) , Birmingham, UK United Kingdom|
Duration: 14 Feb 2016 → 15 Feb 2016
- ovarian cancer
- mathematical model
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- Department of Chemical Engineering - Professor
- Reaction and Catalysis Engineering research unit (RaCE)
- Centre for Integrated Materials, Processes & Structures (IMPS)
- EPSRC Centre for Doctoral Training in Advanced Automotive Propulsion Systems (AAPS CDT)
- Institute for Advanced Automotive Propulsion Systems (IAAPS)
Person: Research & Teaching, Core staff, Affiliate staff