TY - JOUR
T1 - Comparative measurements of pressurised metered dose inhaler (pMDI) stem displacement
AU - Young, P M
AU - Price, R
N1 - ID number: ISI:000252582300011
PY - 2008
Y1 - 2008
N2 - A technique was developed to enable direct measurement of a pressurised metered dose inhaler actuation cycle. Three commercially available 250 mu g.dose(-1) beclomethasone diproprianate formulations were chosen for analysis; Becloforte (Glaxosmithkline, Sussex), Clenil Forte (Chiesi, Parma, Italy), and BDP-Modulite (Chiesi-Glaxosmithkline). The compression cycle of each device was analyzed and the point of drug actuation (force at which drug was released as an aerosol) was determined. Quantitative analysis of three devices from each product suggested no significant variation in inter-batch actuation force (ANOVA, p < 0.05) (N = 3). Interestingly, a significant variation between product type actuation force was observed (ANOVA, p < 0.05) (N = 3). Actuation forces ranged from 22.33 N +/- 1.44 N for Becloforte to 31.12 N +/- 2.73 N for Clenilforte. In general, such observations suggested a maximum difference of 8.7 N between the two extremes, equivalent to a 39% increase in force required to receive a dose.
AB - A technique was developed to enable direct measurement of a pressurised metered dose inhaler actuation cycle. Three commercially available 250 mu g.dose(-1) beclomethasone diproprianate formulations were chosen for analysis; Becloforte (Glaxosmithkline, Sussex), Clenil Forte (Chiesi, Parma, Italy), and BDP-Modulite (Chiesi-Glaxosmithkline). The compression cycle of each device was analyzed and the point of drug actuation (force at which drug was released as an aerosol) was determined. Quantitative analysis of three devices from each product suggested no significant variation in inter-batch actuation force (ANOVA, p < 0.05) (N = 3). Interestingly, a significant variation between product type actuation force was observed (ANOVA, p < 0.05) (N = 3). Actuation forces ranged from 22.33 N +/- 1.44 N for Becloforte to 31.12 N +/- 2.73 N for Clenilforte. In general, such observations suggested a maximum difference of 8.7 N between the two extremes, equivalent to a 39% increase in force required to receive a dose.
UR - http://www.scopus.com/inward/record.url?scp=38549109397&partnerID=8YFLogxK
U2 - 10.1080/03639040701484205
DO - 10.1080/03639040701484205
M3 - Article
SN - 0363-9045
VL - 34
SP - 90
EP - 94
JO - Drug Development and Industrial Pharmacy
JF - Drug Development and Industrial Pharmacy
IS - 1
ER -