Comparative genomic analyses of the Taylorellae

Heidi Hauser, Daniel C Richter, Andries van Tonder, Louise Clark, Andrew Preston

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Contagious equine metritis (CEM) is an important venereal disease of horses that is of concern to the thoroughbred industry. Taylorella equigenitalis is a causative agent of CEM but very little is known about it or its close relative Taylorella asinigenitalis. To reveal novel information about Taylorella biology, comparative genomic analyses were undertaken. Whole genome sequencing was performed for the T. equigenitalis type strain, NCTC11184. Draft genome sequences were produced for a second T. equigenitalis strain and for a strain of T. asinigenitalis. These genome sequences were analysed and compared to each other and the recently released genome sequence of T. equigenitalis MCE9. These analyses revealed that T. equigenitalis strains appear to be very similar to each other with relatively little strain-specific DNA content. A number of genes were identified that encode putative toxins and adhesins that are possibly involved in infection. Analysis of T. asinigenitalis revealed that it has a very similar gene repertoire to that of T. equigenitalis but shares surprisingly little DNA sequence identity with it. The generation of genome sequence information greatly increases knowledge of these poorly characterised bacteria and greatly facilitates study of them.
Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalVeterinary Microbiology
Volume159
Issue number1-2
DOIs
Publication statusPublished - 2012

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Taylorella equigenitalis
Taylorella asinigenitalis
genomics
Taylorella
Genome
genome
contagious equine metritis
Horses
sexually transmitted diseases
adhesins
Sexually Transmitted Diseases
Genes
Industry
toxins
genes
industry
Bacteria
horses
nucleotide sequences
Biological Sciences

Cite this

Comparative genomic analyses of the Taylorellae. / Hauser, Heidi; Richter, Daniel C; van Tonder, Andries; Clark, Louise; Preston, Andrew.

In: Veterinary Microbiology, Vol. 159, No. 1-2, 2012, p. 195-203.

Research output: Contribution to journalArticle

Hauser, H, Richter, DC, van Tonder, A, Clark, L & Preston, A 2012, 'Comparative genomic analyses of the Taylorellae', Veterinary Microbiology, vol. 159, no. 1-2, pp. 195-203. https://doi.org/10.1016/j.vetmic.2012.03.041
Hauser, Heidi ; Richter, Daniel C ; van Tonder, Andries ; Clark, Louise ; Preston, Andrew. / Comparative genomic analyses of the Taylorellae. In: Veterinary Microbiology. 2012 ; Vol. 159, No. 1-2. pp. 195-203.
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