Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica

Julian Parkhill; Mohammed Sebaihia; Andrew Preston; Lee D Murphy; Nicholas Thomson; David E Harris; Matthew T G Holden; Carol M Churcher; Stephen D Bentley; Karen L Mungall; Ana M Cerdeño-Tárraga; Louise Temple; Keith James; Barbara Harris; Michael A Quail; Mark Achtman; Rebecca Atkin; Steven Baker; David Basham; Nathalie Bason; Inna Cherevach; Tracey Chillingworth; Matthew Collins; Anne Cronin; Paul Davis; Jonathan Doggett; Theresa Feltwell; Arlette Goble; Nancy Hamlin; Heidi Hauser; Simon Holroyd; Kay Jagels; Sampsa Leather; Sharon Moule; Halina Norberczak; Susan O'Neil; Doug Ormond; Claire Price; Ester Rabbinowitsch; Simon Rutter; Mandy Sanders; David Saunders; Katherine Seeger; Sarah Sharp; Mark Simmonds; Jason Skelton; Robert Squares; Steven Squares; Kim Stevens; Louise Unwin; Sally Whitehead; Bart G Barrell; Duncan J Maskell

doi:10.1038/ng1227

Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica

Julian Parkhill, Mohammed Sebaihia, Andrew Preston, Lee D Murphy, Nicholas Thomson, David E Harris, Matthew T G Holden, Carol M Churcher, Stephen D Bentley, Karen L Mungall, Ana M Cerdeño-Tárraga, Louise Temple, Keith James, Barbara Harris, Michael A Quail, Mark Achtman, Rebecca Atkin, Steven Baker, David Basham, Nathalie BasonInna Cherevach, Tracey Chillingworth, Matthew Collins, Anne Cronin, Paul Davis, Jonathan Doggett, Theresa Feltwell, Arlette Goble, Nancy Hamlin, Heidi Hauser, Simon Holroyd, Kay Jagels, Sampsa Leather, Sharon Moule, Halina Norberczak, Susan O'Neil, Doug Ormond, Claire Price, Ester Rabbinowitsch, Simon Rutter, Mandy Sanders, David Saunders, Katherine Seeger, Sarah Sharp, Mark Simmonds, Jason Skelton, Robert Squares, Steven Squares, Kim Stevens, Louise Unwin, Sally Whitehead, Bart G Barrell, Duncan J Maskell

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

847 Citations (SciVal)

Abstract

Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative beta-proteobacteria that colonize the respiratory tracts of mammals. B. pertussis is a strict human pathogen of recent evolutionary origin and is the primary etiologic agent of whooping cough. B. parapertussis can also cause whooping cough, and B. bronchiseptica causes chronic respiratory infections in a wide range of animals. We sequenced the genomes of B. bronchiseptica RB50 (5,338,400 bp; 5,007 predicted genes), B. parapertussis 12822 (4,773,551 bp; 4,404 genes) and B. pertussis Tohama I (4,086,186 bp; 3,816 genes). Our analysis indicates that B. parapertussis and B. pertussis are independent derivatives of B. bronchiseptica-like ancestors. During the evolution of these two host-restricted species there was large-scale gene loss and inactivation; host adaptation seems to be a consequence of loss, not gain, of function, and differences in virulence may be related to loss of regulatory or control functions.

Original language	English
Pages (from-to)	32-40
Number of pages	9
Journal	Nature Genetics
Volume	35
Issue number	1
Early online date	9 Aug 2003
DOIs	https://doi.org/10.1038/ng1227
Publication status	Published - 2003

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Parkhill, J., Sebaihia, M., Preston, A., Murphy, L. D., Thomson, N., Harris, D. E., Holden, M. T. G., Churcher, C. M., Bentley, S. D., Mungall, K. L., Cerdeño-Tárraga, A. M., Temple, L., James, K., Harris, B., Quail, M. A., Achtman, M., Atkin, R., Baker, S., Basham, D., ... Maskell, D. J. (2003). Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nature Genetics, 35(1), 32-40. https://doi.org/10.1038/ng1227

Parkhill, J, Sebaihia, M, Preston, A, Murphy, LD, Thomson, N, Harris, DE, Holden, MTG, Churcher, CM, Bentley, SD, Mungall, KL, Cerdeño-Tárraga, AM, Temple, L, James, K, Harris, B, Quail, MA, Achtman, M, Atkin, R, Baker, S, Basham, D, Bason, N, Cherevach, I, Chillingworth, T, Collins, M, Cronin, A, Davis, P, Doggett, J, Feltwell, T, Goble, A, Hamlin, N, Hauser, H, Holroyd, S, Jagels, K, Leather, S, Moule, S, Norberczak, H, O'Neil, S, Ormond, D, Price, C, Rabbinowitsch, E, Rutter, S, Sanders, M, Saunders, D, Seeger, K, Sharp, S, Simmonds, M, Skelton, J, Squares, R, Squares, S, Stevens, K, Unwin, L, Whitehead, S, Barrell, BG & Maskell, DJ 2003, 'Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica', Nature Genetics, vol. 35, no. 1, pp. 32-40. https://doi.org/10.1038/ng1227

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abstract = "Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative beta-proteobacteria that colonize the respiratory tracts of mammals. B. pertussis is a strict human pathogen of recent evolutionary origin and is the primary etiologic agent of whooping cough. B. parapertussis can also cause whooping cough, and B. bronchiseptica causes chronic respiratory infections in a wide range of animals. We sequenced the genomes of B. bronchiseptica RB50 (5,338,400 bp; 5,007 predicted genes), B. parapertussis 12822 (4,773,551 bp; 4,404 genes) and B. pertussis Tohama I (4,086,186 bp; 3,816 genes). Our analysis indicates that B. parapertussis and B. pertussis are independent derivatives of B. bronchiseptica-like ancestors. During the evolution of these two host-restricted species there was large-scale gene loss and inactivation; host adaptation seems to be a consequence of loss, not gain, of function, and differences in virulence may be related to loss of regulatory or control functions.",

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AU - Thomson, Nicholas

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AU - Holden, Matthew T G

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AU - Cronin, Anne

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AU - Doggett, Jonathan

AU - Feltwell, Theresa

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AU - Hamlin, Nancy

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AU - Holroyd, Simon

AU - Jagels, Kay

AU - Leather, Sampsa

AU - Moule, Sharon

AU - Norberczak, Halina

AU - O'Neil, Susan

AU - Ormond, Doug

AU - Price, Claire

AU - Rabbinowitsch, Ester

AU - Rutter, Simon

AU - Sanders, Mandy

AU - Saunders, David

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AU - Barrell, Bart G

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UR - https://www.scopus.com/pages/publications/0042355274

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JO - Nature Genetics

JF - Nature Genetics

IS - 1

ER -

Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica

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