Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis

U Huffmeier, S Uebe, A B Ekici, J Bowes, E Giardina, E Korendowych, K Juneblad, M Apel, R McManus, P Ho, I N Bruce, A W Ryan, F Behrens, J Lascorz, B Bohm, H Traupe, J Lohmann, C Gieger, H E Wichmann, C HeroldM Steffens, L Klareskog, T F Wienker, O FitzGerald, G M Alenius, Neil J McHugh, G Novelli, H Burkhardt, A Barton, A Reis

Research output: Contribution to journalArticle

259 Citations (Scopus)

Abstract

Psoriatic arthritis (PsA) is an inflammatory joint disease that is distinct from other chronic arthritides and which is frequently accompanied by psoriasis vulgaris (PsV) and seronegativity for rheumatoid factor. We conducted a genome-wide association study in 609 German individuals with PsA (cases) and 990 controls with replication in 6 European cohorts including a total of 5,488 individuals. We replicated PsA associations at HLA-C and IL12B and identified a new association at TRAF3IP2 (rs13190932, P = 8.56 x 10(-17)). TRAF3IP2 was also associated with PsV in a German cohort including 2,040 individuals (rs13190932, P = 1.95 x 10(-3)). Sequencing of the exons of TRAF3IP2 identified a coding variant (p.Asp10Asn, rs33980500) as the most significantly associated SNP (P = 1.13 x 10(-20), odds ratio = 1.95). Functional assays showed reduced binding of this TRAF3IP2 variant to TRAF6, suggesting altered modulation of immunoregulatory signals through altered TRAF interactions as a new and shared pathway for PsA and PsV.
Original languageEnglish
Pages (from-to)996-999
Number of pages4
JournalNature Genetics
Volume42
Issue number11
Early online date16 Oct 2010
DOIs
Publication statusPublished - Nov 2010

Fingerprint Dive into the research topics of 'Common variants at <em>TRAF3IP2</em> are associated with susceptibility to psoriatic arthritis and psoriasis'. Together they form a unique fingerprint.

  • Cite this

    Huffmeier, U., Uebe, S., Ekici, A. B., Bowes, J., Giardina, E., Korendowych, E., Juneblad, K., Apel, M., McManus, R., Ho, P., Bruce, I. N., Ryan, A. W., Behrens, F., Lascorz, J., Bohm, B., Traupe, H., Lohmann, J., Gieger, C., Wichmann, H. E., ... Reis, A. (2010). Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. Nature Genetics, 42(11), 996-999. https://doi.org/10.1038/ng.688