TY - JOUR
T1 - Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study
T2 - A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments
AU - Habota, Tina
AU - Sandu, Anca Larisa
AU - Waiter, Gordon D.
AU - McNeil, Christopher J.
AU - Steele, J. Douglas
AU - Macfarlane, Jennifer A.
AU - Whalley, Heather C.
AU - Valentine, Ruth
AU - Younie, Dawn
AU - Crouch, Nichola
AU - Hawkins, Emma L.
AU - Hirose, Yoriko
AU - Romaniuk, Liana
AU - Milburn, Keith
AU - Buchan, Gordon
AU - Coupar, Tessa
AU - Stirling, Mairi
AU - Jagpal, Baljit
AU - MacLennan, Beverly
AU - Priba, Lucasz
AU - Harris, Mathew A.
AU - Hafferty, Jonathan D.
AU - Adams, Mark J.
AU - Campbell, Archie I.
AU - MacIntyre, Donald J.
AU - Pattie, Alison
AU - Murphy, Lee
AU - Reynolds, Rebecca M.
AU - Elliot, Rebecca
AU - Penton-Voak, Ian S.
AU - Munafò, Marcus R.
AU - Evans, Kathryn L.
AU - Seckl, Jonathan R.
AU - Wardlaw, Joanna M.
AU - Lawrie, Stephen M.
AU - Haley, Christopher S.
AU - Porteous, David J.
AU - Deary, Ian J.
AU - Murray, Alison D.
AU - McIntosh, Andrew M.
PY - 2021/7/16
Y1 - 2021/7/16
N2 - STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures relevant to the study of depression, psychological resilience, and cognition. In addition, routinely collected historic NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.
AB - STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures relevant to the study of depression, psychological resilience, and cognition. In addition, routinely collected historic NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.
KW - Cognition
KW - Depression
KW - Generation Scotland
KW - Longitudinal
KW - Neuroimaging
KW - Psychological resilience
UR - http://www.scopus.com/inward/record.url?scp=85125814007&partnerID=8YFLogxK
U2 - 10.12688/wellcomeopenres.15538.2
DO - 10.12688/wellcomeopenres.15538.2
M3 - Article
AN - SCOPUS:85125814007
SN - 2312-0541
VL - 4
JO - Wellcome Open Research
JF - Wellcome Open Research
M1 - 185
ER -