Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1-14 |
| Number of pages | 14 |
| Journal | European Journal of Nutrition |
| DOIs | |
| Publication status | Accepted/In press - 11 Sep 2019 |
Keywords
- incretins
- calcium
- protein
- metabolism
- peptide tyrosine tyrosine
- gastric inhibitory peptide
- postprandial
Cite this
Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: An RCT in healthy adults. / Chen, Yung-Chih; Smith, Harry; Hengist, Aaron; Chrzanowski-Smith, Oliver; Mikkelsen, Ulla Ramer; Carroll, Harriet; Betts, James; Thompson, Dylan; Saunders, John; Gonzalez, Javier.
In: European Journal of Nutrition, 17.11.2019, p. 1-14.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion:
T2 - An RCT in healthy adults
AU - Chen, Yung-Chih
AU - Smith, Harry
AU - Hengist, Aaron
AU - Chrzanowski-Smith, Oliver
AU - Mikkelsen, Ulla Ramer
AU - Carroll, Harriet
AU - Betts, James
AU - Thompson, Dylan
AU - Saunders, John
AU - Gonzalez, Javier
PY - 2019/9/11
Y1 - 2019/9/11
N2 - Purpose: To examine whether calcium type and co-ingestion with protein alters gut hormone availability. Methods: Healthy adults aged 26±7 years (mean±SD) completed three randomized, double-blind, crossover studies. In all studies, arterialized blood was sampled postprandially over 120-min to determine GLP-1, GIP and PYY responses, alongside appetite ratings, energy expenditure and blood pressure. In study one (n=20), three treatments matched for total calcium content (1058 mg) were compared: calcium citrate (CALCITR); milk minerals rich in calcium (MILK MINERALS); and milk minerals rich in calcium plus co-ingestion of 50 g whey protein hydrolysate (MILK MINERALS+PROTEIN). In study two (n=6), 50 g whey protein hydrolysate (PROTEIN) was compared to MILK MINERALS+PROTEIN. In study three (n=6), MILK MINERALS was compared to the vehicle of ingestion (water plus sucralose; CONTROL). Results: MILK MINERALS+PROTEIN increased GLP-1 incremental area under the curve (iAUC) by ~9-fold (43.7±11.1 pmol·L-1·120 min; p<0.001) versus both CALCITR and MILK MINERALS, with no difference detected between CALCITR (6.6±3.7 pmol·L-1·120 min) and MILK MINERALS (5.3±3.5 pmol·L-1·120 min; p>0.999). MILK MINERALS+PROTEIN produced a GLP-1 iAUC ~25% greater than PROTEIN (p=0.024; mean difference: 9.1±6.9 pmol·L-1·120 min), whereas the difference between MILK MINERALS versus CONTROL was small and non-significant (p=0.098; mean difference: 4.2±5.1 pmol·L-1·120 min). Conclusions: When ingested alone, milk minerals rich in calcium do not increase GLP-1 secretion compared to calcium citrate. Co-ingesting high-dose whey protein hydrolysate with milk minerals rich in calcium increases postprandial GLP-1 concentrations to some of the highest physiological levels ever reported. Registered at ClinicalTrials.gov: NCT03232034, NCT03370484, NCT03370497.
AB - Purpose: To examine whether calcium type and co-ingestion with protein alters gut hormone availability. Methods: Healthy adults aged 26±7 years (mean±SD) completed three randomized, double-blind, crossover studies. In all studies, arterialized blood was sampled postprandially over 120-min to determine GLP-1, GIP and PYY responses, alongside appetite ratings, energy expenditure and blood pressure. In study one (n=20), three treatments matched for total calcium content (1058 mg) were compared: calcium citrate (CALCITR); milk minerals rich in calcium (MILK MINERALS); and milk minerals rich in calcium plus co-ingestion of 50 g whey protein hydrolysate (MILK MINERALS+PROTEIN). In study two (n=6), 50 g whey protein hydrolysate (PROTEIN) was compared to MILK MINERALS+PROTEIN. In study three (n=6), MILK MINERALS was compared to the vehicle of ingestion (water plus sucralose; CONTROL). Results: MILK MINERALS+PROTEIN increased GLP-1 incremental area under the curve (iAUC) by ~9-fold (43.7±11.1 pmol·L-1·120 min; p<0.001) versus both CALCITR and MILK MINERALS, with no difference detected between CALCITR (6.6±3.7 pmol·L-1·120 min) and MILK MINERALS (5.3±3.5 pmol·L-1·120 min; p>0.999). MILK MINERALS+PROTEIN produced a GLP-1 iAUC ~25% greater than PROTEIN (p=0.024; mean difference: 9.1±6.9 pmol·L-1·120 min), whereas the difference between MILK MINERALS versus CONTROL was small and non-significant (p=0.098; mean difference: 4.2±5.1 pmol·L-1·120 min). Conclusions: When ingested alone, milk minerals rich in calcium do not increase GLP-1 secretion compared to calcium citrate. Co-ingesting high-dose whey protein hydrolysate with milk minerals rich in calcium increases postprandial GLP-1 concentrations to some of the highest physiological levels ever reported. Registered at ClinicalTrials.gov: NCT03232034, NCT03370484, NCT03370497.
KW - incretins
KW - calcium
KW - protein
KW - metabolism
KW - peptide tyrosine tyrosine
KW - gastric inhibitory peptide
KW - postprandial
U2 - 10.1007/s00394-019-02092-4
DO - 10.1007/s00394-019-02092-4
M3 - Article
SP - 1
EP - 14
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6207
ER -