Co-crystal polymorphic control by nanodroplet and electrical confinement

L. M. Padrela, Bernardo Castro Dominguez, A. Ziaee, B. Long, K. M. Ryan, G. Walker, E. J. O'Reilly

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The polymorphic control of the co-crystal carbamazepine–saccharin (CBZ–SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ–SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.
Original languageEnglish
Pages (from-to)2845-2848
Number of pages4
JournalCrystEngComm
Volume2019
Issue number18
Early online date18 Apr 2019
DOIs
Publication statusPublished - 14 May 2019

Cite this

Padrela, L. M., Castro Dominguez, B., Ziaee, A., Long, B., Ryan, K. M., Walker, G., & O'Reilly, E. J. (2019). Co-crystal polymorphic control by nanodroplet and electrical confinement. CrystEngComm, 2019(18), 2845-2848. https://doi.org/10.1039/C9CE00060G

Co-crystal polymorphic control by nanodroplet and electrical confinement. / Padrela, L. M.; Castro Dominguez, Bernardo; Ziaee, A.; Long, B.; Ryan, K. M.; Walker, G.; O'Reilly, E. J.

In: CrystEngComm, Vol. 2019, No. 18, 14.05.2019, p. 2845-2848.

Research output: Contribution to journalArticle

Padrela, LM, Castro Dominguez, B, Ziaee, A, Long, B, Ryan, KM, Walker, G & O'Reilly, EJ 2019, 'Co-crystal polymorphic control by nanodroplet and electrical confinement', CrystEngComm, vol. 2019, no. 18, pp. 2845-2848. https://doi.org/10.1039/C9CE00060G
Padrela, L. M. ; Castro Dominguez, Bernardo ; Ziaee, A. ; Long, B. ; Ryan, K. M. ; Walker, G. ; O'Reilly, E. J. / Co-crystal polymorphic control by nanodroplet and electrical confinement. In: CrystEngComm. 2019 ; Vol. 2019, No. 18. pp. 2845-2848.
@article{6348986b90ec4af19acdcf003b58c3df,
title = "Co-crystal polymorphic control by nanodroplet and electrical confinement",
abstract = "The polymorphic control of the co-crystal carbamazepine–saccharin (CBZ–SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ–SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.",
author = "Padrela, {L. M.} and {Castro Dominguez}, Bernardo and A. Ziaee and B. Long and Ryan, {K. M.} and G. Walker and O'Reilly, {E. J.}",
year = "2019",
month = "5",
day = "14",
doi = "10.1039/C9CE00060G",
language = "English",
volume = "2019",
pages = "2845--2848",
journal = "CrystEngComm",
issn = "1466-8033",
publisher = "Royal Society of Chemistry",
number = "18",

}

TY - JOUR

T1 - Co-crystal polymorphic control by nanodroplet and electrical confinement

AU - Padrela, L. M.

AU - Castro Dominguez, Bernardo

AU - Ziaee, A.

AU - Long, B.

AU - Ryan, K. M.

AU - Walker, G.

AU - O'Reilly, E. J.

PY - 2019/5/14

Y1 - 2019/5/14

N2 - The polymorphic control of the co-crystal carbamazepine–saccharin (CBZ–SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ–SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.

AB - The polymorphic control of the co-crystal carbamazepine–saccharin (CBZ–SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ–SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.

U2 - 10.1039/C9CE00060G

DO - 10.1039/C9CE00060G

M3 - Article

VL - 2019

SP - 2845

EP - 2848

JO - CrystEngComm

JF - CrystEngComm

SN - 1466-8033

IS - 18

ER -