Co-crystal polymorphic control by nanodroplet and electrical confinement

L. M. Padrela; Bernardo Castro Dominguez; A. Ziaee; B. Long; K. M. Ryan; G. Walker; E. J. O'Reilly

doi:10.1039/C9CE00060G

Co-crystal polymorphic control by nanodroplet and electrical confinement

L. M. Padrela, Bernardo Castro Dominguez, A. Ziaee, B. Long, K. M. Ryan, G. Walker, E. J. O'Reilly

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

16 Citations (SciVal)

Abstract

The polymorphic control of the co-crystal carbamazepine–saccharin (CBZ–SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ–SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.

Original language	English
Pages (from-to)	2845-2848
Number of pages	4
Journal	CrystEngComm
Volume	2019
Issue number	18
Early online date	18 Apr 2019
DOIs	https://doi.org/10.1039/C9CE00060G
Publication status	Published - 14 May 2019

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abstract = "The polymorphic control of the co-crystal carbamazepine–saccharin (CBZ–SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ–SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.",

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AU - Padrela, L. M.

AU - Castro Dominguez, Bernardo

AU - Ziaee, A.

AU - Long, B.

AU - Ryan, K. M.

AU - Walker, G.

AU - O'Reilly, E. J.

PY - 2019/5/14

Y1 - 2019/5/14

N2 - The polymorphic control of the co-crystal carbamazepine–saccharin (CBZ–SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ–SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.

AB - The polymorphic control of the co-crystal carbamazepine–saccharin (CBZ–SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ–SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.

U2 - 10.1039/C9CE00060G

DO - 10.1039/C9CE00060G

M3 - Article

SN - 1466-8033

VL - 2019

SP - 2845

EP - 2848

JO - CrystEngComm

JF - CrystEngComm

IS - 18

ER -

Co-crystal polymorphic control by nanodroplet and electrical confinement

Abstract

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