The polymorphic control of the co-crystal carbamazepine–saccharin (CBZ–SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ–SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.
Padrela, L. M., Castro Dominguez, B., Ziaee, A., Long, B., Ryan, K. M., Walker, G., & O'Reilly, E. J. (2019). Co-crystal polymorphic control by nanodroplet and electrical confinement. CrystEngComm, 2019(18), 2845-2848. https://doi.org/10.1039/C9CE00060G