@inbook{d19f90efacce42debbba47d919615b9f,
title = "Clot Structure and Implications for Bleeding and Thrombosis",
abstract = "The formation of a fibrin clot matrix plays a critical role in promoting hemostasis and wound healing. Fibrin dynamics can become disadvantageous in the formation of aberrant thrombus development. Structural characteristics of clots, such as fiber diameter, clot density, stiffness, or permeability, can determine overall clot integrity and functional characteristics that have implications on coagulation and fibrinolysis. This review examines known factors that contribute to changes in clot structure and the presence of structural clot changes in various disease states. These insights provide valuable information in forming therapeutic strategies for disease states where alterations in clot structure are observed. Additionally, the implications of structural changes in clot networks on bleeding and thrombus development in terms of disease states and clinical outcomes are also examined in this review.",
keywords = "atomic force microscopy, clot structure, fibrin, fibrinolysis, thrombosis",
author = "Oliver Hammond and Karen Edler",
note = "Funding Information: Our work as described in this review was supported by the American Heart Association (16SDG29870005), National Institutes of Health NIAMS (R21AR071017), and the North Carolina State University GAANN Fellowship in Molecular Biotechnology and AHA Pre-doctoral Fellowship (18PRE33990338) to E.M. Publisher Copyright: {\textcopyright} 2020 Royal Society of Chemistry. All rights reserved.",
year = "2020",
month = jan,
day = "31",
doi = "10.1055/s-0039-1696944",
language = "English",
isbn = "978-3-527-34518-2",
volume = "46",
series = "Seminars in Thrombosis and Hemostasis",
publisher = "John Wiley and Sons Inc.",
pages = "96--97",
editor = "Ramon, {Diego J.} and Gabriela Guillena",
booktitle = "Deep Eutectic Solvents: Synthesis, Properties and Applications",
address = "USA United States",
edition = "1",
}