Clot Structure and Implications for Bleeding and Thrombosis

Oliver Hammond, Karen Edler

Research output: Chapter or section in a book/report/conference proceedingChapter or section

28 Citations (SciVal)


The formation of a fibrin clot matrix plays a critical role in promoting hemostasis and wound healing. Fibrin dynamics can become disadvantageous in the formation of aberrant thrombus development. Structural characteristics of clots, such as fiber diameter, clot density, stiffness, or permeability, can determine overall clot integrity and functional characteristics that have implications on coagulation and fibrinolysis. This review examines known factors that contribute to changes in clot structure and the presence of structural clot changes in various disease states. These insights provide valuable information in forming therapeutic strategies for disease states where alterations in clot structure are observed. Additionally, the implications of structural changes in clot networks on bleeding and thrombus development in terms of disease states and clinical outcomes are also examined in this review.

Original languageEnglish
Title of host publicationDeep Eutectic Solvents: Synthesis, Properties and Applications
EditorsDiego J. Ramon, Gabriela Guillena
PublisherJohn Wiley & Sons
Number of pages2
ISBN (Electronic)978-3-527-81849-5
ISBN (Print)978-3-527-34518-2
Publication statusPublished - 31 Jan 2020

Publication series

NameSeminars in Thrombosis and Hemostasis
ISSN (Print)0094-6176

Bibliographical note

Funding Information:
Our work as described in this review was supported by the American Heart Association (16SDG29870005), National Institutes of Health NIAMS (R21AR071017), and the North Carolina State University GAANN Fellowship in Molecular Biotechnology and AHA Pre-doctoral Fellowship (18PRE33990338) to E.M.

Publisher Copyright:
© 2020 Royal Society of Chemistry. All rights reserved.


  • atomic force microscopy
  • clot structure
  • fibrin
  • fibrinolysis
  • thrombosis

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine


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