Human sirtuin 1 is a member of the histone deacetylase family and is involved in cellular aging, tumourigenesis and cellular metabolism. Recombinant sirtuin 1 comprising residues 140-747 was crystallized using the hanging-drop vapour-diffusion method. The crystal diffracted to 3.4 A resolution and belonged to space group P622, with unit-cell parameters a = b = 203.1, c = 625.3 A, and is estimated to contain between six and 12 molecules per asymmetric unit.
|Number of pages||3|
|Journal||Acta Crystallographica Section F-Structural Biology and Crystallization Communications|
|Publication status||Published - Apr 2011|
- sirtuin 1
- histone deacetylases