Clinical and Economic Burden of Pneumococcal Disease Among Individuals Aged 16 Years and Older in Germany

Arijita Deb, Bélène Podmore, Rosemarie Barnett, Dominik Beier, Wolfgang Galetzka, Nawab Qizilbash, Dennis Haeckl, Sarah Mihm, Kelly Johnson, Thomas Weiss

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2 Citations (SciVal)


This study assessed the incidence rate of all-cause pneumonia (ACP) and invasive pneumococcal disease (IPD) and associated medical costs among individuals aged ?16 in the German InGef database from 2016 to 2019. Incidence rate was expressed as the number of episodes per 100000 person-years (PY). Healthcare resource utilization was investigated by age group and by risk group (healthy, at-risk, high-risk). Direct medical costs per ACP/IPD episode were estimated as the total costs of all inpatient and outpatient visits. The overall incidence rate of ACP was 1345 (95% CI 1339-1352) and 8.25 (95% CI 7.76-8.77) per 100000 PY for IPD. For both ACP and IPD, incidence rates increased with age and were higher in the high-risk and at-risk groups, in comparison to the healthy group. ACP inpatient admission rate increased with age but remained steady across age-groups for IPD. The mean direct medical costs per episode were 8075 (95% CI 7121-9028) for IPD and 1454 (95% CI 1426-1482) for ACP. The aggregate direct medical costs for IPD and ACP episodes were estimated to be 8.5 million and 248.9 million respectively. The clinical and economic burden of IPD and ACP among German adults is substantial regardless of age.

Original languageEnglish
Article numbere204
JournalEpidemiology and Infection
Early online date8 Nov 2022
Publication statusPublished - 31 Dec 2022


  • Germany
  • all-cause pneumonia
  • claims data
  • healthcare resource utilization
  • invasive pneumococcal disease

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases


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