'Click cyclic ADP-ribose': A neutral second messenger mimic

Joanna M. Swarbrick; Richard Graeff; Clive Garnham; Mark P. Thomas; Antony Galione; Barry V. L. Potter

doi:10.1039/c3cc49249d

'Click cyclic ADP-ribose': A neutral second messenger mimic

Joanna M. Swarbrick
, Richard Graeff
, Clive Garnham
, Mark P. Thomas
, Antony Galione
, Barry V. L. Potter

Department of Life Sciences

University of Hong Kong
University of Oxford

Research output: Contribution to journal › Article › peer-review

27 Citations (SciVal)

218 Downloads (Pure)

Abstract

Analogues of the potent Ca2+ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca 2+ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators

Original language	English
Pages (from-to)	2458-2461
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	19
DOIs	https://doi.org/10.1039/c3cc49249d
Publication status	Published - 7 Mar 2014

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Final published version, 1.22 MBLicence: CC BY

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abstract = "Analogues of the potent Ca2+ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca 2+ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators",

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AU - Galione, Antony

AU - Potter, Barry V. L.

PY - 2014/3/7

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N2 - Analogues of the potent Ca2+ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca 2+ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators

AB - Analogues of the potent Ca2+ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca 2+ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators

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'Click cyclic ADP-ribose': A neutral second messenger mimic

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Chemical Biology of Cellular Signalling using Polyphosphate Messengers

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'Click cyclic ADP-ribose': A neutral second messenger mimic

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Chemical Biology of Cellular Signalling using Polyphosphate Messengers

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