TY - JOUR
T1 - 'Click cyclic ADP-ribose'
T2 - A neutral second messenger mimic
AU - Swarbrick, Joanna M.
AU - Graeff, Richard
AU - Garnham, Clive
AU - Thomas, Mark P.
AU - Galione, Antony
AU - Potter, Barry V. L.
PY - 2014/3/7
Y1 - 2014/3/7
N2 - Analogues of the potent Ca2+ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca 2+ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators
AB - Analogues of the potent Ca2+ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca 2+ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators
UR - http://www.scopus.com/inward/record.url?scp=84893827216&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1039/c3cc49249d
U2 - 10.1039/c3cc49249d
DO - 10.1039/c3cc49249d
M3 - Article
SN - 1359-7345
VL - 50
SP - 2458
EP - 2461
JO - Chemical communications (Cambridge, England)
JF - Chemical communications (Cambridge, England)
IS - 19
ER -