'Click cyclic ADP-ribose': A neutral second messenger mimic

Joanna M. Swarbrick, Richard Graeff, Clive Garnham, Mark P. Thomas, Antony Galione, Barry V. L. Potter

Research output: Contribution to journalArticlepeer-review

26 Citations (SciVal)
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Analogues of the potent Ca2+ releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca 2+ release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators
Original languageEnglish
Pages (from-to)2458-2461
Number of pages4
JournalChemical Communications
Issue number19
Publication statusPublished - 7 Mar 2014


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