Projects per year
Rate variation among the sites of a molecular sequence is commonly found in applications of phylogenetic inference. Several approaches exist to account for this feature but they do not usually enable the investigator to pinpoint the sites that evolve under one or another rate of evolution in a straightforward manner. The focus is on Bayesian phylogenetic mixture models, augmented with allocation variables, as tools for site classification and quantification of classification uncertainty. The method does not rely on prior knowledge of site membership to classes or even the number of classes. Furthermore, it does not require correlated sites to be next to one another in the sequence alignment, unlike some phylogenetic hidden Markov or change-point models. In the approach presented, model selection on the number and type of mixture components is conducted ahead of both model estimation and site classification; the steppingstone sampler (SS) is used to select amongst competing mixture models. Example applications of simulated data and mitochondrial DNA of primates illustrate site classification via 'augmented' Bayesian phylogenetic mixtures. In both examples, all mixtures outperform commonly-used models of among-site rate variation and models that do not account for rate heterogeneity. The examples further demonstrate how site classification is readily available from the analysis output. The method is directly relevant to the choice of partitions in Bayesian phylogenetics, and its application may lead to the discovery of structure not otherwise recognised in a molecular sequence alignment. Computational aspects of Bayesian phylogenetic model estimation are discussed, including the use of simple Markov chain Monte Carlo (MCMC) moves that mix efficiently without tempering the chains. The contribution to the field of Bayesian phylogenetics is in (1) the use of mixture models augmented with allocation variables as tools for site classification and quantification of classification uncertainty, (2) the successful application of SS for selection of phylogenetic mixtures, and (3) the development of novel MCMC aspects of relevance to Bayesian phylogenetic models-whether mixtures or not.1 1 The MCMC methods discussed in this paper have been coded in a C program; source files are available upon request. Supplementary material is available online (see Appendix A).
|Number of pages||15|
|Journal||Computational Statistics & Data Analysis|
|Early online date||29 Jan 2014|
|Publication status||Published - 1 Jul 2014|
- among-site rate variation
- Bayesian mixture model
- Markov chain Monte Carlo
- model selection
FingerprintDive into the research topics of 'Classification of molecular sequence data using Bayesian phylogenetic mixture models'. Together they form a unique fingerprint.
- 1 Finished
ESTABLISHMENT OF THE UNIVERSITY OF BATH CENTRE FOR COMPLEX S YSTEMS - O/HEAD SPLIT SM75% EN25%
Budd, C., Almond, D., Britton, N., Hunt, G., Hurn, M. & Smyshlyaev, V. P.
Engineering and Physical Sciences Research Council
29/11/04 → 28/11/09
Project: Research council
- Department of Mathematical Sciences - Senior Lecturer
Person: Research & Teaching