Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis

Adam J. Causer; Janis K. Shute; Michael H. Cummings; Anthony I. Shepherd; Mathieu Gruet; Joseph T. Costello; Stephen Bailey; Martin Lindley; Clare Pearson; Gary Connett; Mark I. Allenby; Mary P. Carroll; Thomas Daniels; Zoe L. Saynor

doi:10.1016/j.redox.2020.101436

Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis

Adam J. Causer, Janis K. Shute, Michael H. Cummings, Anthony I. Shepherd, Mathieu Gruet, Joseph T. Costello, Stephen Bailey, Martin Lindley, Clare Pearson, Gary Connett, Mark I. Allenby, Mary P. Carroll, Thomas Daniels, Zoe L. Saynor

Department for Health

Research output: Contribution to journal › Review article › peer-review

37 Citations (SciVal)

Abstract

Introduction Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances. Methods Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI). Results Forty-nine studies were eligible for this review including a total of 1792 people with CF and 1675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: −0.66, 95% CI -1.14 to −0.17) and E (SMD: −0.74, 95% CI: −1.28 to −0.20), β-carotene (SMD: −1.80, 95% CI: −2.92 to −0.67), lutein (SMD: −1.52, 95% CI: −1.83 to −1.20) and albumin (SMD: −0.98, 95% CI: −1.68 to −0.27) were significantly lower in the plasma or serum of people with CF versus controls. Conclusions This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.

Original language	English
Article number	101436
Pages (from-to)	101436
Journal	Redox Biology
Volume	32
Early online date	23 Jan 2020
DOIs	https://doi.org/10.1016/j.redox.2020.101436
Publication status	Published - May 2020

Bibliographical note

Keywords

Biological markers
Glutathione
Minerals
Oxidoreductases
Redox imbalance
Respiratory disease
Vitamins

ASJC Scopus subject areas

Organic Chemistry
Clinical Biochemistry

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10.1016/j.redox.2020.101436Licence: CC BY

http://www.sciencedirect.com/science/article/pii/S2213231719313679

Cite this

Causer, A. J., Shute, J. K., Cummings, M. H., Shepherd, A. I., Gruet, M., Costello, J. T., Bailey, S., Lindley, M., Pearson, C., Connett, G., Allenby, M. I., Carroll, M. P., Daniels, T., & Saynor, Z. L. (2020). Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis. Redox Biology, 32, 101436. Article 101436. https://doi.org/10.1016/j.redox.2020.101436

Causer, AJ, Shute, JK, Cummings, MH, Shepherd, AI, Gruet, M, Costello, JT, Bailey, S, Lindley, M, Pearson, C, Connett, G, Allenby, MI, Carroll, MP, Daniels, T & Saynor, ZL 2020, 'Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis', Redox Biology, vol. 32, 101436, pp. 101436. https://doi.org/10.1016/j.redox.2020.101436

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title = "Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis",

abstract = "Introduction Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances. Methods Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI). Results Forty-nine studies were eligible for this review including a total of 1792 people with CF and 1675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: −0.66, 95% CI -1.14 to −0.17) and E (SMD: −0.74, 95% CI: −1.28 to −0.20), β-carotene (SMD: −1.80, 95% CI: −2.92 to −0.67), lutein (SMD: −1.52, 95% CI: −1.83 to −1.20) and albumin (SMD: −0.98, 95% CI: −1.68 to −0.27) were significantly lower in the plasma or serum of people with CF versus controls. Conclusions This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.",

keywords = "Biological markers, Glutathione, Minerals, Oxidoreductases, Redox imbalance, Respiratory disease, Vitamins",

author = "Causer, {Adam J.} and Shute, {Janis K.} and Cummings, {Michael H.} and Shepherd, {Anthony I.} and Mathieu Gruet and Costello, {Joseph T.} and Stephen Bailey and Martin Lindley and Clare Pearson and Gary Connett and Allenby, {Mark I.} and Carroll, {Mary P.} and Thomas Daniels and Saynor, {Zoe L.}",

year = "2020",

month = may,

doi = "10.1016/j.redox.2020.101436",

language = "English",

volume = "32",

pages = "101436",

journal = "Redox Biology",

issn = "2213-2317",

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T1 - Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis

AU - Causer, Adam J.

AU - Shute, Janis K.

AU - Cummings, Michael H.

AU - Shepherd, Anthony I.

AU - Gruet, Mathieu

AU - Costello, Joseph T.

AU - Bailey, Stephen

AU - Lindley, Martin

AU - Pearson, Clare

AU - Connett, Gary

AU - Allenby, Mark I.

AU - Carroll, Mary P.

AU - Daniels, Thomas

AU - Saynor, Zoe L.

PY - 2020/5

Y1 - 2020/5

N2 - Introduction Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances. Methods Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI). Results Forty-nine studies were eligible for this review including a total of 1792 people with CF and 1675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: −0.66, 95% CI -1.14 to −0.17) and E (SMD: −0.74, 95% CI: −1.28 to −0.20), β-carotene (SMD: −1.80, 95% CI: −2.92 to −0.67), lutein (SMD: −1.52, 95% CI: −1.83 to −1.20) and albumin (SMD: −0.98, 95% CI: −1.68 to −0.27) were significantly lower in the plasma or serum of people with CF versus controls. Conclusions This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.

AB - Introduction Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances. Methods Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI). Results Forty-nine studies were eligible for this review including a total of 1792 people with CF and 1675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: −0.66, 95% CI -1.14 to −0.17) and E (SMD: −0.74, 95% CI: −1.28 to −0.20), β-carotene (SMD: −1.80, 95% CI: −2.92 to −0.67), lutein (SMD: −1.52, 95% CI: −1.83 to −1.20) and albumin (SMD: −0.98, 95% CI: −1.68 to −0.27) were significantly lower in the plasma or serum of people with CF versus controls. Conclusions This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.

KW - Biological markers

KW - Glutathione

KW - Minerals

KW - Oxidoreductases

KW - Redox imbalance

KW - Respiratory disease

KW - Vitamins

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DO - 10.1016/j.redox.2020.101436

M3 - Review article

C2 - 32044291

SN - 2213-2317

VL - 32

SP - 101436

JO - Redox Biology

JF - Redox Biology

M1 - 101436

ER -

Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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