Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis

Adam J. Causer, Janis K. Shute, Michael H. Cummings, Anthony I. Shepherd, Mathieu Gruet, Joseph T. Costello, Stephen Bailey, Martin Lindley, Clare Pearson, Gary Connett, Mark I. Allenby, Mary P. Carroll, Thomas Daniels, Zoe L. Saynor

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Introduction Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances. Methods Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI). Results Forty-nine studies were eligible for this review including a total of 1792 people with CF and 1675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: −0.66, 95% CI -1.14 to −0.17) and E (SMD: −0.74, 95% CI: −1.28 to −0.20), β-carotene (SMD: −1.80, 95% CI: −2.92 to −0.67), lutein (SMD: −1.52, 95% CI: −1.83 to −1.20) and albumin (SMD: −0.98, 95% CI: −1.68 to −0.27) were significantly lower in the plasma or serum of people with CF versus controls. Conclusions This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.
Original languageEnglish
Article number101436
Pages (from-to)101436
JournalRedox Biology
Volume32
Early online date23 Jan 2020
DOIs
Publication statusPublished - May 2020

Keywords

  • Biological markers
  • Glutathione
  • Minerals
  • Oxidoreductases
  • Redox imbalance
  • Respiratory disease
  • Vitamins

ASJC Scopus subject areas

  • Organic Chemistry
  • Clinical Biochemistry

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