Chromatin remodelling is a major source of coexpression of linked genes in yeast

N N Batada, A O Urrutia, L D Hurst

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

In diverse organisms, neighbouring genes in the genome tend to be positively coexpressed more than expected by chance. When the similarity of transcription regulation is controlled for, adjacent genes have much higher coexpression rates than unlinked genes, supporting a role for chromatin modelling. Consequently, many incidences of low-to-moderate level coexpression of linked genes might well be spurious rather than an indication of functional coordination. These results have implications for gene therapy and for understanding gene order evolution, suggesting that chromosomal proximity alone is adequate to achieve some level of coexpression.
Original languageEnglish
Pages (from-to)480-484
Number of pages5
JournalTrends in Genetics
Volume23
Issue number10
DOIs
Publication statusPublished - 2007

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