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CHOLIX-DERIVED DELIVERY CONSTRUCT

  • Julia MacKay (Inventor)
  • , Randall Mrsny (Inventor)
  • , Alistair Taverner (Inventor)
  • University of Bath

Research output: Patent

Abstract

The present invention provides a delivery construct comprising: (a) a transport facilitator comprising an immunoglobulin CH2 domain; (b) a transporter comprising a cholix domain Ia; and (c) a therapeutic cargo; wherein the transporter is cleavably coupled to the therapeutic cargo and wherein the transport facilitator is N-terminal to the transporter. Also provided are pharmaceutical compositions comprising the delivery construct.

Original languageEnglish
Patent numberWO2026078256
IPCC07K 14/ 28 A I
Priority date11/10/24
Publication statusPublished - 16 Apr 2026

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