Cholesterol induced suppression of large swelling of water layer in phosphocholine floating bilayers

B Stidder; G Fragneto; R Cubitt; A V Hughes; S J Roser

doi:10.1021/la050611a

Cholesterol induced suppression of large swelling of water layer in phosphocholine floating bilayers

B Stidder
, G Fragneto
, R Cubitt
, A V Hughes
, S J Roser

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

17 Citations (SciVal)

Abstract

The effect of the addition of 10 mol % cholesterol to 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) floating bilayers has been investigated by means of neutron reflectivity measurements. The large swelling of the water layer between the two bilayers found in pure phosphocholine systems around the lipid main phase transition(1) is greatly reduced in the 9:1 DPPC:cholesterol mixture. The analysis of the structure of the bilayer reveals that in the gel phase cholesterol induces the presence of a high rms roughness that disappears in the fluid phase.

Original language	English
Pages (from-to)	8703-8710
Number of pages	8
Journal	Langmuir
Volume	21
Issue number	19
DOIs	https://doi.org/10.1021/la050611a
Publication status	Published - 2005

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ID number: ISI:000231789800026

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10.1021/la050611a

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title = "Cholesterol induced suppression of large swelling of water layer in phosphocholine floating bilayers",

abstract = "The effect of the addition of 10 mol \% cholesterol to 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) floating bilayers has been investigated by means of neutron reflectivity measurements. The large swelling of the water layer between the two bilayers found in pure phosphocholine systems around the lipid main phase transition(1) is greatly reduced in the 9:1 DPPC:cholesterol mixture. The analysis of the structure of the bilayer reveals that in the gel phase cholesterol induces the presence of a high rms roughness that disappears in the fluid phase.",

author = "B Stidder and G Fragneto and R Cubitt and Hughes, \{A V\} and Roser, \{S J\}",

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journal = "Langmuir",

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T1 - Cholesterol induced suppression of large swelling of water layer in phosphocholine floating bilayers

AU - Stidder, B

AU - Fragneto, G

AU - Cubitt, R

AU - Hughes, A V

AU - Roser, S J

N1 - ID number: ISI:000231789800026

PY - 2005

Y1 - 2005

N2 - The effect of the addition of 10 mol % cholesterol to 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) floating bilayers has been investigated by means of neutron reflectivity measurements. The large swelling of the water layer between the two bilayers found in pure phosphocholine systems around the lipid main phase transition(1) is greatly reduced in the 9:1 DPPC:cholesterol mixture. The analysis of the structure of the bilayer reveals that in the gel phase cholesterol induces the presence of a high rms roughness that disappears in the fluid phase.

AB - The effect of the addition of 10 mol % cholesterol to 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) floating bilayers has been investigated by means of neutron reflectivity measurements. The large swelling of the water layer between the two bilayers found in pure phosphocholine systems around the lipid main phase transition(1) is greatly reduced in the 9:1 DPPC:cholesterol mixture. The analysis of the structure of the bilayer reveals that in the gel phase cholesterol induces the presence of a high rms roughness that disappears in the fluid phase.

U2 - 10.1021/la050611a

DO - 10.1021/la050611a

M3 - Article

SN - 0743-7463

VL - 21

SP - 8703

EP - 8710

JO - Langmuir

JF - Langmuir

IS - 19

ER -

Cholesterol induced suppression of large swelling of water layer in phosphocholine floating bilayers

Abstract

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