Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen

Timothy J Woodman, Pauline J Wood, Andrew S Thompson, T J Hutchings, G R Steel, P Jiao, Michael D Threadgill, Matthew D Lloyd

Research output: Contribution to journalArticle

27 Citations (Scopus)
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Abstract

Metabolic chiral inversion of 2-arylpropanoic acids (2-APAs;double dagger 'profens'), such as ibuprofen, is important for pharmacological activity. Several 2-APA-CoA esters were good racemisation substrates for human AMACR 1A, suggesting a common chiral inversion pathway for all 2-APAs and an additional mechanism for their anti-cancer properties.
Original languageEnglish
Pages (from-to)7332-7334
Number of pages3
JournalChemical Communications
Volume47
Issue number26
Early online date25 May 2011
DOIs
Publication statusPublished - 14 Jul 2011

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