Chiral Au(I) and Au(III)- isothiourea Complexes: Synthesis, Characterization and Application

Danila Gasperini, Mark D. Greenhalgh, Rehan Imad, Shezaib Siddiqui, Anum Malik, Fizza Arshad, Muhammad I. Choudhary, Abdullah M. Al-Majid, David Cordes, Alexandra M.z. Slawin, Steven P. Nolan, Andrew Smith

Research output: Contribution to journalArticle

Abstract

During the invesigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesizes and fully characterized. The steric and electronic properties of the isothiurea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(II)-isothiourea catbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biologicl studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.
Original languageEnglish
Pages (from-to)1064-1075
Number of pages9
JournalChemistry - A European Journal
Volume25
Issue number4
Early online date24 Oct 2018
DOIs
Publication statusPublished - 22 Jan 2019

Keywords

  • bioinorganic chemistry
  • coordination chemistry
  • gold
  • homogeneous catalysis
  • N ligands

Cite this

Chiral Au(I) and Au(III)- isothiourea Complexes: Synthesis, Characterization and Application. / Gasperini, Danila; Greenhalgh, Mark D.; Imad, Rehan; Siddiqui, Shezaib ; Malik, Anum; Arshad, Fizza; Choudhary, Muhammad I.; Al-Majid, Abdullah M.; Cordes, David; Slawin, Alexandra M.z.; Nolan, Steven P.; Smith, Andrew.

In: Chemistry - A European Journal, Vol. 25, No. 4, 22.01.2019, p. 1064-1075.

Research output: Contribution to journalArticle

Gasperini, D, Greenhalgh, MD, Imad, R, Siddiqui, S, Malik, A, Arshad, F, Choudhary, MI, Al-Majid, AM, Cordes, D, Slawin, AMZ, Nolan, SP & Smith, A 2019, 'Chiral Au(I) and Au(III)- isothiourea Complexes: Synthesis, Characterization and Application', Chemistry - A European Journal, vol. 25, no. 4, pp. 1064-1075. https://doi.org/10.1002/chem.201804653
Gasperini, Danila ; Greenhalgh, Mark D. ; Imad, Rehan ; Siddiqui, Shezaib ; Malik, Anum ; Arshad, Fizza ; Choudhary, Muhammad I. ; Al-Majid, Abdullah M. ; Cordes, David ; Slawin, Alexandra M.z. ; Nolan, Steven P. ; Smith, Andrew. / Chiral Au(I) and Au(III)- isothiourea Complexes: Synthesis, Characterization and Application. In: Chemistry - A European Journal. 2019 ; Vol. 25, No. 4. pp. 1064-1075.
@article{2fd962f061864c1b8b628da24f3ea816,
title = "Chiral Au(I) and Au(III)- isothiourea Complexes: Synthesis, Characterization and Application",
abstract = "During the invesigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesizes and fully characterized. The steric and electronic properties of the isothiurea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(II)-isothiourea catbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biologicl studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.",
keywords = "bioinorganic chemistry, coordination chemistry, gold, homogeneous catalysis, N ligands",
author = "Danila Gasperini and Greenhalgh, {Mark D.} and Rehan Imad and Shezaib Siddiqui and Anum Malik and Fizza Arshad and Choudhary, {Muhammad I.} and Al-Majid, {Abdullah M.} and David Cordes and Slawin, {Alexandra M.z.} and Nolan, {Steven P.} and Andrew Smith",
year = "2019",
month = "1",
day = "22",
doi = "10.1002/chem.201804653",
language = "English",
volume = "25",
pages = "1064--1075",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Chiral Au(I) and Au(III)- isothiourea Complexes: Synthesis, Characterization and Application

AU - Gasperini, Danila

AU - Greenhalgh, Mark D.

AU - Imad, Rehan

AU - Siddiqui, Shezaib

AU - Malik, Anum

AU - Arshad, Fizza

AU - Choudhary, Muhammad I.

AU - Al-Majid, Abdullah M.

AU - Cordes, David

AU - Slawin, Alexandra M.z.

AU - Nolan, Steven P.

AU - Smith, Andrew

PY - 2019/1/22

Y1 - 2019/1/22

N2 - During the invesigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesizes and fully characterized. The steric and electronic properties of the isothiurea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(II)-isothiourea catbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biologicl studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.

AB - During the invesigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesizes and fully characterized. The steric and electronic properties of the isothiurea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(II)-isothiourea catbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biologicl studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.

KW - bioinorganic chemistry

KW - coordination chemistry

KW - gold

KW - homogeneous catalysis

KW - N ligands

U2 - 10.1002/chem.201804653

DO - 10.1002/chem.201804653

M3 - Article

VL - 25

SP - 1064

EP - 1075

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 4

ER -