Chiral Au(I) and Au(III)- isothiourea Complexes: Synthesis, Characterization and Application

Danila Gasperini, Mark D. Greenhalgh, Rehan Imad, Shezaib Siddiqui, Anum Malik, Fizza Arshad, Muhammad I. Choudhary, Abdullah M. Al-Majid, David Cordes, Alexandra M.z. Slawin, Steven P. Nolan, Andrew Smith

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

During an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized. The steric and electronic properties of the isothiourea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(I)-isothiourea carbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biological studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.

Original languageEnglish
Pages (from-to)1064-1075
Number of pages12
JournalChemistry - A European Journal
Volume25
Issue number4
Early online date24 Oct 2018
DOIs
Publication statusPublished - 18 Jan 2019

Keywords

  • N ligands
  • bioinorganic chemistry
  • coordination chemistry
  • gold
  • homogeneous catalysis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

Cite this

Gasperini, D., Greenhalgh, M. D., Imad, R., Siddiqui, S., Malik, A., Arshad, F., Choudhary, M. I., Al-Majid, A. M., Cordes, D., Slawin, A. M. Z., Nolan, S. P., & Smith, A. (2019). Chiral Au(I) and Au(III)- isothiourea Complexes: Synthesis, Characterization and Application. Chemistry - A European Journal, 25(4), 1064-1075. https://doi.org/10.1002/chem.201804653