TY - JOUR
T1 - Chemotherapy dosing part II
T2 - alternative approaches and future prospects
AU - Kaestner, S. A.
AU - Sewell, Graham J.
N1 - ID number: ISI:000244584000001
PY - 2007/3
Y1 - 2007/3
N2 - This overview follows on from part I, which described the current practices used in chemotherapy dosing and the paucity of scientific evidence to support them. In part II, alternative approaches are discussed, both in terms of scientific rationale and practical application. These include therapeutic drug monitoring, the use of pharmacokinetic-pharmacodynamic relationships, flat-fixed dosing, Bayesian modelling and dose banding.
AB - This overview follows on from part I, which described the current practices used in chemotherapy dosing and the paucity of scientific evidence to support them. In part II, alternative approaches are discussed, both in terms of scientific rationale and practical application. These include therapeutic drug monitoring, the use of pharmacokinetic-pharmacodynamic relationships, flat-fixed dosing, Bayesian modelling and dose banding.
UR - http://dx.doi.org/10.1016/j.clon.2006.10.003
U2 - 10.1016/j.clon.2006.10.003
DO - 10.1016/j.clon.2006.10.003
M3 - Article
SN - 0936-6555
VL - 19
SP - 99
EP - 107
JO - Clinical Oncology
JF - Clinical Oncology
IS - 2
ER -