Chemotherapy dosing part II: alternative approaches and future prospects

S. A. Kaestner; Graham J. Sewell

doi:10.1016/j.clon.2006.10.003

Chemotherapy dosing part II: alternative approaches and future prospects

S. A. Kaestner, Graham J. Sewell

Department of Pharmacy & Pharmacology

Research output: Contribution to journal › Article › peer-review

14 Citations (SciVal)

Abstract

This overview follows on from part I, which described the current practices used in chemotherapy dosing and the paucity of scientific evidence to support them. In part II, alternative approaches are discussed, both in terms of scientific rationale and practical application. These include therapeutic drug monitoring, the use of pharmacokinetic-pharmacodynamic relationships, flat-fixed dosing, Bayesian modelling and dose banding.

Original language	English
Pages (from-to)	99-107
Number of pages	9
Journal	Clinical Oncology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/j.clon.2006.10.003
Publication status	Published - Mar 2007

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10.1016/j.clon.2006.10.003

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title = "Chemotherapy dosing part II: alternative approaches and future prospects",

abstract = "This overview follows on from part I, which described the current practices used in chemotherapy dosing and the paucity of scientific evidence to support them. In part II, alternative approaches are discussed, both in terms of scientific rationale and practical application. These include therapeutic drug monitoring, the use of pharmacokinetic-pharmacodynamic relationships, flat-fixed dosing, Bayesian modelling and dose banding.",

author = "Kaestner, {S. A.} and Sewell, {Graham J.}",

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T2 - alternative approaches and future prospects

AU - Kaestner, S. A.

AU - Sewell, Graham J.

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N2 - This overview follows on from part I, which described the current practices used in chemotherapy dosing and the paucity of scientific evidence to support them. In part II, alternative approaches are discussed, both in terms of scientific rationale and practical application. These include therapeutic drug monitoring, the use of pharmacokinetic-pharmacodynamic relationships, flat-fixed dosing, Bayesian modelling and dose banding.

AB - This overview follows on from part I, which described the current practices used in chemotherapy dosing and the paucity of scientific evidence to support them. In part II, alternative approaches are discussed, both in terms of scientific rationale and practical application. These include therapeutic drug monitoring, the use of pharmacokinetic-pharmacodynamic relationships, flat-fixed dosing, Bayesian modelling and dose banding.

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DO - 10.1016/j.clon.2006.10.003

M3 - Article

VL - 19

SP - 99

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JO - Clinical Oncology

JF - Clinical Oncology

SN - 0936-6555

IS - 2

ER -

Chemotherapy dosing part II: alternative approaches and future prospects

Abstract

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