Chemical modification of mammalian cell surfaces

Barrie Kellam, Paul A. De Bank, Kevin M. Shakesheff

Research output: Contribution to journalArticlepeer-review

89 Citations (SciVal)


The mammalian cell surface is a highly heterogeneous chemical environment with proteins, carbohydrates, lipids and composite molecules controlling vital cell functions. Chemical modification of this environment is a challenge due to the complexity of the surface chemistry and the fragility of the cell. Here, we review recent attempts to perform targeted, non-genetically controlled, changes to cell surface chemistry. Potential applications of cell surface engineering are presented.
Original languageEnglish
Pages (from-to)327-337
Number of pages11
JournalChemical Society Reviews
Issue number6
Publication statusPublished - Nov 2003


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