Chemical biology probes of mammalian GLUT structure and function

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The structure and function of glucose transporters of the mammalian GLUT family of proteins has been studied over many decades, and the proteins have fascinated numerous research groups over this time. This interest is related to the importance of the GLUTs as archetypical membrane transport facilitators, as key limiters of the supply of glucose to cell metabolism, as targets of cell insulin and exercise signalling and of regulated membrane traffic, and as potential drug targets to combat cancer and metabolic diseases such as type 2 diabetes and obesity. This review focusses on the use of chemical biology approaches and sugar analogue probes to study these important proteins.

Original languageEnglish
Pages (from-to)3511-3534
Number of pages24
JournalThe Biochemical journal
Volume475
Issue number22
DOIs
Publication statusPublished - 20 Nov 2018

Keywords

  • GLUT proteins
  • GLUT4 translocation
  • insulin action

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Chemical biology probes of mammalian GLUT structure and function. / Holman, Geoffrey D.

In: The Biochemical journal, Vol. 475, No. 22, 20.11.2018, p. 3511-3534.

Research output: Contribution to journalReview article

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