Abstract
The administration of 5-aminolevulinic acid (ALA) to generate enhanced intracellular levels of endogenous porphyrins is currently one of the most important approaches for photodynamic therapy (PDT) and photodiagnosis (PDD). Despite the great promise of ALA-based PDT, the physicochemical behaviour and chemical reactivity of ALA are problematic, and a variety of chemical approaches have been brought to bear to improve cellular delivery, enhance porphyrin production, and generate ALA prodrugs that have appropriate stability for convenient clinical use, as well as selectivity for cancerous tissues. While there has been considerable success, there are still a number of challenges to be addressed and opportunities to be exploited through application of chemical insight in this area.
| Original language | English |
|---|---|
| Pages (from-to) | 1553-1572 |
| Number of pages | 20 |
| Journal | Photochemical and Photobiological Sciences |
| Volume | 17 |
| Issue number | 11 |
| Early online date | 8 Oct 2018 |
| DOIs | |
| Publication status | Published - 1 Nov 2018 |
Keywords
- Aminolevulinic Acid/administration & dosage
- Antineoplastic Agents/administration & dosage
- Humans
- Neoplasms/diagnosis
- Photochemotherapy
- Photosensitizing Agents/administration & dosage
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
Cite this
Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis. / Tewari, Kunal M.; Eggleston, Ian M.
In: Photochemical and Photobiological Sciences, Vol. 17, No. 11, 01.11.2018, p. 1553-1572.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis
AU - Tewari, Kunal M.
AU - Eggleston, Ian M.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - The administration of 5-aminolevulinic acid (ALA) to generate enhanced intracellular levels of endogenous porphyrins is currently one of the most important approaches for photodynamic therapy (PDT) and photodiagnosis (PDD). Despite the great promise of ALA-based PDT, the physicochemical behaviour and chemical reactivity of ALA are problematic, and a variety of chemical approaches have been brought to bear to improve cellular delivery, enhance porphyrin production, and generate ALA prodrugs that have appropriate stability for convenient clinical use, as well as selectivity for cancerous tissues. While there has been considerable success, there are still a number of challenges to be addressed and opportunities to be exploited through application of chemical insight in this area.
AB - The administration of 5-aminolevulinic acid (ALA) to generate enhanced intracellular levels of endogenous porphyrins is currently one of the most important approaches for photodynamic therapy (PDT) and photodiagnosis (PDD). Despite the great promise of ALA-based PDT, the physicochemical behaviour and chemical reactivity of ALA are problematic, and a variety of chemical approaches have been brought to bear to improve cellular delivery, enhance porphyrin production, and generate ALA prodrugs that have appropriate stability for convenient clinical use, as well as selectivity for cancerous tissues. While there has been considerable success, there are still a number of challenges to be addressed and opportunities to be exploited through application of chemical insight in this area.
KW - Aminolevulinic Acid/administration & dosage
KW - Antineoplastic Agents/administration & dosage
KW - Humans
KW - Neoplasms/diagnosis
KW - Photochemotherapy
KW - Photosensitizing Agents/administration & dosage
UR - http://www.scopus.com/inward/record.url?scp=85056345594&partnerID=8YFLogxK
U2 - 10.1039/c8pp00362a
DO - 10.1039/c8pp00362a
M3 - Review article
VL - 17
SP - 1553
EP - 1572
JO - Photochemical & Photobiological Sciences
JF - Photochemical & Photobiological Sciences
SN - 1474-905X
IS - 11
ER -