Chemical amplification of magnetic field effects relevant to avian magnetoreception

Daniel Kattnig, Emrys Evans, Victoire Dejean, Charlotte Dodson, Mark Wallace, Stuart Mackenzie, Christiane Timmel, Peter Hore

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Magnetic fields as weak as the Earth's can change the yields of radical pair reactions even though the energies involved are orders of magnitude smaller than the thermal energy, k(B)T, at room temperature. Proposed as the source of the light-dependent magnetic compass in migratory birds, the radical pair mechanism is thought to operate in cryptochrome flavoproteins in the retina. Here we demonstrate that the primary magnetic field effect on flavin photoreactions can be amplified chemically by slow radical termination reactions under conditions of continuous photoexcitation. The nature and origin of the amplification are revealed by studies of the intermolecular flavin-tryptophan and flavin-ascorbic acid photocycles and the closely related intramolecular flavin-tryptophan radical pair in cryptochrome. Amplification factors of up to 5.6 were observed for magnetic fields weaker than 1 mT. Substantial chemical amplification could have a significant impact on the viability of a cryptochrome-based magnetic compass sensor.
Original languageEnglish
Pages (from-to)384-391
Number of pages8
JournalNature Chemistry
Volume8
DOIs
Publication statusPublished - 1 Feb 2016

Fingerprint

Magnetic field effects
Cryptochromes
Amplification
Tryptophan
Magnetic fields
Photoexcitation
Ascorbic acid
Birds
Thermal energy
Flavoproteins
Light sources
Earth (planet)
Ascorbic Acid
Sensors
4,6-dinitro-o-cresol
Temperature

Cite this

Kattnig, D., Evans, E., Dejean, V., Dodson, C., Wallace, M., Mackenzie, S., ... Hore, P. (2016). Chemical amplification of magnetic field effects relevant to avian magnetoreception. Nature Chemistry, 8, 384-391. https://doi.org/10.1038/NCHEM.2447

Chemical amplification of magnetic field effects relevant to avian magnetoreception. / Kattnig, Daniel; Evans, Emrys; Dejean, Victoire; Dodson, Charlotte; Wallace, Mark; Mackenzie, Stuart; Timmel, Christiane; Hore, Peter.

In: Nature Chemistry, Vol. 8, 01.02.2016, p. 384-391.

Research output: Contribution to journalArticle

Kattnig, D, Evans, E, Dejean, V, Dodson, C, Wallace, M, Mackenzie, S, Timmel, C & Hore, P 2016, 'Chemical amplification of magnetic field effects relevant to avian magnetoreception', Nature Chemistry, vol. 8, pp. 384-391. https://doi.org/10.1038/NCHEM.2447
Kattnig, Daniel ; Evans, Emrys ; Dejean, Victoire ; Dodson, Charlotte ; Wallace, Mark ; Mackenzie, Stuart ; Timmel, Christiane ; Hore, Peter. / Chemical amplification of magnetic field effects relevant to avian magnetoreception. In: Nature Chemistry. 2016 ; Vol. 8. pp. 384-391.
@article{3a17a7b739ee4cde9b073e024ead58c3,
title = "Chemical amplification of magnetic field effects relevant to avian magnetoreception",
abstract = "Magnetic fields as weak as the Earth's can change the yields of radical pair reactions even though the energies involved are orders of magnitude smaller than the thermal energy, k(B)T, at room temperature. Proposed as the source of the light-dependent magnetic compass in migratory birds, the radical pair mechanism is thought to operate in cryptochrome flavoproteins in the retina. Here we demonstrate that the primary magnetic field effect on flavin photoreactions can be amplified chemically by slow radical termination reactions under conditions of continuous photoexcitation. The nature and origin of the amplification are revealed by studies of the intermolecular flavin-tryptophan and flavin-ascorbic acid photocycles and the closely related intramolecular flavin-tryptophan radical pair in cryptochrome. Amplification factors of up to 5.6 were observed for magnetic fields weaker than 1 mT. Substantial chemical amplification could have a significant impact on the viability of a cryptochrome-based magnetic compass sensor.",
author = "Daniel Kattnig and Emrys Evans and Victoire Dejean and Charlotte Dodson and Mark Wallace and Stuart Mackenzie and Christiane Timmel and Peter Hore",
year = "2016",
month = "2",
day = "1",
doi = "10.1038/NCHEM.2447",
language = "English",
volume = "8",
pages = "384--391",
journal = "Nature Chemistry",
issn = "1755-4330",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Chemical amplification of magnetic field effects relevant to avian magnetoreception

AU - Kattnig, Daniel

AU - Evans, Emrys

AU - Dejean, Victoire

AU - Dodson, Charlotte

AU - Wallace, Mark

AU - Mackenzie, Stuart

AU - Timmel, Christiane

AU - Hore, Peter

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Magnetic fields as weak as the Earth's can change the yields of radical pair reactions even though the energies involved are orders of magnitude smaller than the thermal energy, k(B)T, at room temperature. Proposed as the source of the light-dependent magnetic compass in migratory birds, the radical pair mechanism is thought to operate in cryptochrome flavoproteins in the retina. Here we demonstrate that the primary magnetic field effect on flavin photoreactions can be amplified chemically by slow radical termination reactions under conditions of continuous photoexcitation. The nature and origin of the amplification are revealed by studies of the intermolecular flavin-tryptophan and flavin-ascorbic acid photocycles and the closely related intramolecular flavin-tryptophan radical pair in cryptochrome. Amplification factors of up to 5.6 were observed for magnetic fields weaker than 1 mT. Substantial chemical amplification could have a significant impact on the viability of a cryptochrome-based magnetic compass sensor.

AB - Magnetic fields as weak as the Earth's can change the yields of radical pair reactions even though the energies involved are orders of magnitude smaller than the thermal energy, k(B)T, at room temperature. Proposed as the source of the light-dependent magnetic compass in migratory birds, the radical pair mechanism is thought to operate in cryptochrome flavoproteins in the retina. Here we demonstrate that the primary magnetic field effect on flavin photoreactions can be amplified chemically by slow radical termination reactions under conditions of continuous photoexcitation. The nature and origin of the amplification are revealed by studies of the intermolecular flavin-tryptophan and flavin-ascorbic acid photocycles and the closely related intramolecular flavin-tryptophan radical pair in cryptochrome. Amplification factors of up to 5.6 were observed for magnetic fields weaker than 1 mT. Substantial chemical amplification could have a significant impact on the viability of a cryptochrome-based magnetic compass sensor.

U2 - 10.1038/NCHEM.2447

DO - 10.1038/NCHEM.2447

M3 - Article

VL - 8

SP - 384

EP - 391

JO - Nature Chemistry

JF - Nature Chemistry

SN - 1755-4330

ER -