Abstract
The electronic transmission properties of DNA molecules are believed to play a significant role in many physical phenomena taking place in living organisms (Chakraborty, 2007) [1]. Here we study the charge transport (CT) properties of cancer-related genes, including some of the most important tumor suppressors. We find that the changes in averaged CT around the sites of pathogenic and cancerous mutations are statistically smaller than those on sites where pathogenic mutations have not been observed. The results suggest that CT might be an indicator to discriminate between pathogenic and non-pathogenic mutations at an early stage. Mutations which cause little change in CT may be more likely to occur, or more likely to be missed by damage-repair enzymes which probe CT, and are therefore more likely to persist and cause disease.
| Original language | English |
|---|---|
| Pages (from-to) | 36-38 |
| Number of pages | 3 |
| Journal | Computer Physics Communications |
| Volume | 182 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2011 |
Access to Document
- Author's accepted version
NOTICE: this is the author’s version of a work that was accepted for publication in Computer Physics Communications. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Computer Physics Communications, vol 182, issue 1, 2011, DOI 10.1016/j.cpc.2010.06.029