Characterization of [3H]Harmane Binding to Rat Whole Brain Membranes

N J Anderson, E S J Robinson, Stephen M Husbands, P Delagrange, D J Nutt, A L Hudson

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

This study investigates the binding of [3H]harmane to rat whole brain homogenates. Saturation studies revealed [3H]harmane labels a single, saturable, high-capacity population with high affinity. All the test compounds displaced [3H]harmane completely and in an apparently monophasic manner. The displacement profile of the test ligands indicated labeling of MAO-A. Given the high level of MAO-A binding, it is unlikely that a low-capacity I2 site would be distinguishable from the total [3H]harmane population.
Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume1009
Issue number1
DOIs
Publication statusPublished - 2003

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