Characterisation and functionality of inhalation anhydrous lactose

Chonladda Pitchayajittipong, Robert Price, Jagdeep Shur, J S Kaerger, S Edge

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The relationships between the physicochemical properties and functionality in dry powder inhaler (DPI) performance was investigated for inhalation grade anhydrous lactose and compared to monohydrate grades. The excipients were characterised using a range of techniques including particle size analysis, moisture sorption and powder rheometry. The inhalation anhydrous lactose grades were readily characterisable. The aerosolisation performance of capsule based DPI formulations containing budesonide (200 mu g) and different grades of lactose evaluated using inertial impaction measurements produced fine particle doses of budesonide ranging from 24 to 49 mu g. There were no apparent relationships between aerosolisation performance and excipient characteristics, such as particle size and powder density. However, formulations containing lactose grades which exhibit higher powder fluidisation energy values resulted in higher fine particle doses of budesonide.
Original languageEnglish
Pages (from-to)134-141
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume390
Issue number2
DOIs
Publication statusPublished - 10 May 2010

Fingerprint

Lactose
Budesonide
Inhalation
Dry Powder Inhalers
Powders
Excipients
Particle Size
Capsules

Keywords

  • powder fluidisation
  • anhydrous lactose
  • dry powder inhaler

Cite this

Characterisation and functionality of inhalation anhydrous lactose. / Pitchayajittipong, Chonladda; Price, Robert; Shur, Jagdeep; Kaerger, J S; Edge, S.

In: International Journal of Pharmaceutics, Vol. 390, No. 2, 10.05.2010, p. 134-141.

Research output: Contribution to journalArticle

Pitchayajittipong, Chonladda ; Price, Robert ; Shur, Jagdeep ; Kaerger, J S ; Edge, S. / Characterisation and functionality of inhalation anhydrous lactose. In: International Journal of Pharmaceutics. 2010 ; Vol. 390, No. 2. pp. 134-141.
@article{81b29a34873c4a3fb64e8d595500d12c,
title = "Characterisation and functionality of inhalation anhydrous lactose",
abstract = "The relationships between the physicochemical properties and functionality in dry powder inhaler (DPI) performance was investigated for inhalation grade anhydrous lactose and compared to monohydrate grades. The excipients were characterised using a range of techniques including particle size analysis, moisture sorption and powder rheometry. The inhalation anhydrous lactose grades were readily characterisable. The aerosolisation performance of capsule based DPI formulations containing budesonide (200 mu g) and different grades of lactose evaluated using inertial impaction measurements produced fine particle doses of budesonide ranging from 24 to 49 mu g. There were no apparent relationships between aerosolisation performance and excipient characteristics, such as particle size and powder density. However, formulations containing lactose grades which exhibit higher powder fluidisation energy values resulted in higher fine particle doses of budesonide.",
keywords = "powder fluidisation, anhydrous lactose, dry powder inhaler",
author = "Chonladda Pitchayajittipong and Robert Price and Jagdeep Shur and Kaerger, {J S} and S Edge",
year = "2010",
month = "5",
day = "10",
doi = "10.1016/j.ijpharm.2010.01.028",
language = "English",
volume = "390",
pages = "134--141",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Characterisation and functionality of inhalation anhydrous lactose

AU - Pitchayajittipong, Chonladda

AU - Price, Robert

AU - Shur, Jagdeep

AU - Kaerger, J S

AU - Edge, S

PY - 2010/5/10

Y1 - 2010/5/10

N2 - The relationships between the physicochemical properties and functionality in dry powder inhaler (DPI) performance was investigated for inhalation grade anhydrous lactose and compared to monohydrate grades. The excipients were characterised using a range of techniques including particle size analysis, moisture sorption and powder rheometry. The inhalation anhydrous lactose grades were readily characterisable. The aerosolisation performance of capsule based DPI formulations containing budesonide (200 mu g) and different grades of lactose evaluated using inertial impaction measurements produced fine particle doses of budesonide ranging from 24 to 49 mu g. There were no apparent relationships between aerosolisation performance and excipient characteristics, such as particle size and powder density. However, formulations containing lactose grades which exhibit higher powder fluidisation energy values resulted in higher fine particle doses of budesonide.

AB - The relationships between the physicochemical properties and functionality in dry powder inhaler (DPI) performance was investigated for inhalation grade anhydrous lactose and compared to monohydrate grades. The excipients were characterised using a range of techniques including particle size analysis, moisture sorption and powder rheometry. The inhalation anhydrous lactose grades were readily characterisable. The aerosolisation performance of capsule based DPI formulations containing budesonide (200 mu g) and different grades of lactose evaluated using inertial impaction measurements produced fine particle doses of budesonide ranging from 24 to 49 mu g. There were no apparent relationships between aerosolisation performance and excipient characteristics, such as particle size and powder density. However, formulations containing lactose grades which exhibit higher powder fluidisation energy values resulted in higher fine particle doses of budesonide.

KW - powder fluidisation

KW - anhydrous lactose

KW - dry powder inhaler

UR - http://www.scopus.com/inward/record.url?scp=77951499720&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1016/j.ijpharm.2010.01.028

U2 - 10.1016/j.ijpharm.2010.01.028

DO - 10.1016/j.ijpharm.2010.01.028

M3 - Article

VL - 390

SP - 134

EP - 141

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2

ER -