1 Citation (Scopus)

Abstract

Anticentromere antibodies (ACA) recognise a family of proteins that remain in the centromere region of eukaryotic cells throughout the cell cycle. The three main centromere proteins recognised (CENP-A, CENP-B and CENP-C) localise to separate parts of the centromeric heterochromatin and closely associated kinetochore, and together form targets for a polyclonal autoantibody response. Antibodies to the centromere associated proteins ( CENPs ) are highly useful probes for understanding the mechanisms that regulate higher order chromosome structure and cell division. Full-length clones for the three main CENP antigens have been isolated and Enzyme-linked immunosorbent assay (ELISAs) using recombinant CENP proteins perform well. ACA are most often found in a group of patients with a limited cutaneous form of systemic sclerosis who are predominantly female, and have a relatively favourable outcome apart from a risk of pulmonary hypertension. ACA may occur but are less often found in other autoimmune connective-tissue disorders. Anti-CENP-C antibodies alone may be found in some patients with primary Sjogren's. Anti-CENP-F antibodies have been reported with certain neoplasms. Genetic factors that influence the ACA development include an extended Major Histocompatibility Complex (MHC) gene haplotype. CENP-B and CENP-C generate unique fragments following exposure to granzyme-B that may offer insight into the mechanism of autoantibody generation.

Original languageEnglish
Title of host publicationAutoantibodies
EditorsY. Shoenfeld, M. E. Gerschwin
PublisherElsevier Academic Press Inc
Pages151-157
Number of pages7
ISBN (Print)9780444527639
DOIs
Publication statusPublished - 1 Dec 2007

Fingerprint

Centromere
Autoantibodies
Centromere Protein B
Protein C
Proteins
Antibodies
Chromosome Structures
Kinetochores
Granzymes
Cells
Heterochromatin
Systemic Scleroderma
Staphylococcal Protein A
Eukaryotic Cells
Immunosorbents
Major Histocompatibility Complex
Pulmonary Hypertension
Cell Division
Connective Tissue
Haplotypes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

John McHugh, N. (2007). Centromere autoantibodies. In Y. Shoenfeld, & M. E. Gerschwin (Eds.), Autoantibodies (pp. 151-157). Elsevier Academic Press Inc. https://doi.org/10.1016/B978-044452763-9/50024-X

Centromere autoantibodies. / John McHugh, Neil.

Autoantibodies. ed. / Y. Shoenfeld; M. E. Gerschwin. Elsevier Academic Press Inc, 2007. p. 151-157.

Research output: Chapter in Book/Report/Conference proceedingChapter

John McHugh, N 2007, Centromere autoantibodies. in Y Shoenfeld & ME Gerschwin (eds), Autoantibodies. Elsevier Academic Press Inc, pp. 151-157. https://doi.org/10.1016/B978-044452763-9/50024-X
John McHugh N. Centromere autoantibodies. In Shoenfeld Y, Gerschwin ME, editors, Autoantibodies. Elsevier Academic Press Inc. 2007. p. 151-157 https://doi.org/10.1016/B978-044452763-9/50024-X
John McHugh, Neil. / Centromere autoantibodies. Autoantibodies. editor / Y. Shoenfeld ; M. E. Gerschwin. Elsevier Academic Press Inc, 2007. pp. 151-157
@inbook{4c3661506ec64b54929485b44a83a834,
title = "Centromere autoantibodies",
abstract = "Anticentromere antibodies (ACA) recognise a family of proteins that remain in the centromere region of eukaryotic cells throughout the cell cycle. The three main centromere proteins recognised (CENP-A, CENP-B and CENP-C) localise to separate parts of the centromeric heterochromatin and closely associated kinetochore, and together form targets for a polyclonal autoantibody response. Antibodies to the centromere associated proteins ( CENPs ) are highly useful probes for understanding the mechanisms that regulate higher order chromosome structure and cell division. Full-length clones for the three main CENP antigens have been isolated and Enzyme-linked immunosorbent assay (ELISAs) using recombinant CENP proteins perform well. ACA are most often found in a group of patients with a limited cutaneous form of systemic sclerosis who are predominantly female, and have a relatively favourable outcome apart from a risk of pulmonary hypertension. ACA may occur but are less often found in other autoimmune connective-tissue disorders. Anti-CENP-C antibodies alone may be found in some patients with primary Sjogren's. Anti-CENP-F antibodies have been reported with certain neoplasms. Genetic factors that influence the ACA development include an extended Major Histocompatibility Complex (MHC) gene haplotype. CENP-B and CENP-C generate unique fragments following exposure to granzyme-B that may offer insight into the mechanism of autoantibody generation.",
author = "{John McHugh}, Neil",
year = "2007",
month = "12",
day = "1",
doi = "10.1016/B978-044452763-9/50024-X",
language = "English",
isbn = "9780444527639",
pages = "151--157",
editor = "Y. Shoenfeld and Gerschwin, {M. E.}",
booktitle = "Autoantibodies",
publisher = "Elsevier Academic Press Inc",
address = "USA United States",

}

TY - CHAP

T1 - Centromere autoantibodies

AU - John McHugh, Neil

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Anticentromere antibodies (ACA) recognise a family of proteins that remain in the centromere region of eukaryotic cells throughout the cell cycle. The three main centromere proteins recognised (CENP-A, CENP-B and CENP-C) localise to separate parts of the centromeric heterochromatin and closely associated kinetochore, and together form targets for a polyclonal autoantibody response. Antibodies to the centromere associated proteins ( CENPs ) are highly useful probes for understanding the mechanisms that regulate higher order chromosome structure and cell division. Full-length clones for the three main CENP antigens have been isolated and Enzyme-linked immunosorbent assay (ELISAs) using recombinant CENP proteins perform well. ACA are most often found in a group of patients with a limited cutaneous form of systemic sclerosis who are predominantly female, and have a relatively favourable outcome apart from a risk of pulmonary hypertension. ACA may occur but are less often found in other autoimmune connective-tissue disorders. Anti-CENP-C antibodies alone may be found in some patients with primary Sjogren's. Anti-CENP-F antibodies have been reported with certain neoplasms. Genetic factors that influence the ACA development include an extended Major Histocompatibility Complex (MHC) gene haplotype. CENP-B and CENP-C generate unique fragments following exposure to granzyme-B that may offer insight into the mechanism of autoantibody generation.

AB - Anticentromere antibodies (ACA) recognise a family of proteins that remain in the centromere region of eukaryotic cells throughout the cell cycle. The three main centromere proteins recognised (CENP-A, CENP-B and CENP-C) localise to separate parts of the centromeric heterochromatin and closely associated kinetochore, and together form targets for a polyclonal autoantibody response. Antibodies to the centromere associated proteins ( CENPs ) are highly useful probes for understanding the mechanisms that regulate higher order chromosome structure and cell division. Full-length clones for the three main CENP antigens have been isolated and Enzyme-linked immunosorbent assay (ELISAs) using recombinant CENP proteins perform well. ACA are most often found in a group of patients with a limited cutaneous form of systemic sclerosis who are predominantly female, and have a relatively favourable outcome apart from a risk of pulmonary hypertension. ACA may occur but are less often found in other autoimmune connective-tissue disorders. Anti-CENP-C antibodies alone may be found in some patients with primary Sjogren's. Anti-CENP-F antibodies have been reported with certain neoplasms. Genetic factors that influence the ACA development include an extended Major Histocompatibility Complex (MHC) gene haplotype. CENP-B and CENP-C generate unique fragments following exposure to granzyme-B that may offer insight into the mechanism of autoantibody generation.

UR - http://www.scopus.com/inward/record.url?scp=84859728472&partnerID=8YFLogxK

U2 - 10.1016/B978-044452763-9/50024-X

DO - 10.1016/B978-044452763-9/50024-X

M3 - Chapter

SN - 9780444527639

SP - 151

EP - 157

BT - Autoantibodies

A2 - Shoenfeld, Y.

A2 - Gerschwin, M. E.

PB - Elsevier Academic Press Inc

ER -