1 Citation (SciVal)


Anticentromere antibodies (ACA) recognise a family of proteins that remain in the centromere region of eukaryotic cells throughout the cell cycle. The three main centromere proteins recognised (CENP-A, CENP-B and CENP-C) localise to separate parts of the centromeric heterochromatin and closely associated kinetochore, and together form targets for a polyclonal autoantibody response. Antibodies to the centromere associated proteins ( CENPs ) are highly useful probes for understanding the mechanisms that regulate higher order chromosome structure and cell division. Full-length clones for the three main CENP antigens have been isolated and Enzyme-linked immunosorbent assay (ELISAs) using recombinant CENP proteins perform well. ACA are most often found in a group of patients with a limited cutaneous form of systemic sclerosis who are predominantly female, and have a relatively favourable outcome apart from a risk of pulmonary hypertension. ACA may occur but are less often found in other autoimmune connective-tissue disorders. Anti-CENP-C antibodies alone may be found in some patients with primary Sjogren's. Anti-CENP-F antibodies have been reported with certain neoplasms. Genetic factors that influence the ACA development include an extended Major Histocompatibility Complex (MHC) gene haplotype. CENP-B and CENP-C generate unique fragments following exposure to granzyme-B that may offer insight into the mechanism of autoantibody generation.

Original languageEnglish
Title of host publicationAutoantibodies
EditorsY. Shoenfeld, M. E. Gerschwin
PublisherElsevier Academic Press Inc
Number of pages7
ISBN (Print)9780444527639
Publication statusPublished - 1 Dec 2007

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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