Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function

Sophie L. Russell; Mushidur Rahman; Charles James Steward; Amy Elizabeth Harwood; Gordon McGregor; Prithwish Banerjee; Nduka Okwose; Djordje Jakovljevic

doi:10.1002/hsr2.70155

Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function

Sophie L. Russell, Mushidur Rahman, Charles James Steward, Amy Elizabeth Harwood, Gordon McGregor, Prithwish Banerjee, Nduka Okwose, Djordje Jakovljevic

Department for Health

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Aims: Arterial function (specifically arterial stiffness) is an important cardiovascular risk factor. Pulse wave velocity (PWV) and augmentation index (Al (Formula presented.)) are established indicators of arterial function. The present study aimed to evaluate the repeatability and reproducibility of PWV and Al (Formula presented.) in healthy individuals. Methods: Forty healthy participants (age 33 ± 11 years, 17 females) underwent resting supine PWV and Al (Formula presented.) assessments. Measurements were made in triplicate and repeated 1 week apart. Al (Formula presented.) was measured by brachial occlusion and PWV was measured from the carotid artery to the femoral artery via the tonometer-oscillometric method. Repeatability and reproducibility were assessed using the intraclass correlation coefficient (ICC). Interoperator reproducibility was performed on 10 participants. Results: The average values for week-to-week visits for PWV and Al (Formula presented.) were 6.20 ± 0.91 versus 6.13 ± 0.91 ms ⁻¹ and 14.0 ± 11.8 versus 16.3 ± 12.2% respectively. For same-day measurements, both PWV and Al (Formula presented.) showed excellent repeatability (PWV: ICC = 0.96, 95% CI: 0.92–0.98, p < 0.01; Al (Formula presented.) : ICC = 0.90, 95% CI: 0.84–0.94, p < 0.01) and interoperator reproducibility (PWV: ICC = 0.98, 95% CI: 0.93–1.00, p < 0.01; Al (Formula presented.) : ICC = 0.93, 95% CI: 0.69–0.98, p < 0.01). Measurements were repeated 1 week apart and showed good reproducibility (PWV: ICC = 0.77, 95% CI: 0.61–0.87, p ≤ 0.01; Al (Formula presented.) : ICC = 0.73, 95% CI: 0.73–0.86, p < 0.01). Conclusion: PWV and Al (Formula presented.) demonstrate excellent repeatability and good reproducibility. Considering these variables are noninvasive and easy-to-measure, arterial function assessment may have a role in routine clinical practice to facilitate risk stratification in cardiovascular diseases.

Original language	English
Article number	e70155
Journal	Health Science Reports
Volume	7
Issue number	11
Early online date	28 Oct 2024
DOIs	https://doi.org/10.1002/hsr2.70155
Publication status	Published - 28 Oct 2024

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Funding

This work was funded by the Coventry University PhD studentship awarded to SLR. DGJ and NCO are supported by the European Horizon 2020 Research and Innovation Programme under grant agreement number 952603. The design of the study, data collection, analyses, interpretation of data, and drafting of the manuscript do not reflect the views and opinions of the funders.

Funders	Funder number
European Horizon 2020 Research and Innovation Programme	952603

Keywords

arterial function
augmentation index
pulse wave velocity
reliability

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hsr2.70155Licence: CC BY

Cite this

@article{f80f3e4746d54ceaa4337e8af60db30b,

title = "Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function",

abstract = "Background and Aims: Arterial function (specifically arterial stiffness) is an important cardiovascular risk factor. Pulse wave velocity (PWV) and augmentation index (Al (Formula presented.)) are established indicators of arterial function. The present study aimed to evaluate the repeatability and reproducibility of PWV and Al (Formula presented.) in healthy individuals. Methods: Forty healthy participants (age 33 ± 11 years, 17 females) underwent resting supine PWV and Al (Formula presented.) assessments. Measurements were made in triplicate and repeated 1 week apart. Al (Formula presented.) was measured by brachial occlusion and PWV was measured from the carotid artery to the femoral artery via the tonometer-oscillometric method. Repeatability and reproducibility were assessed using the intraclass correlation coefficient (ICC). Interoperator reproducibility was performed on 10 participants. Results: The average values for week-to-week visits for PWV and Al (Formula presented.) were 6.20 ± 0.91 versus 6.13 ± 0.91 ms −1 and 14.0 ± 11.8 versus 16.3 ± 12.2% respectively. For same-day measurements, both PWV and Al (Formula presented.) showed excellent repeatability (PWV: ICC = 0.96, 95% CI: 0.92–0.98, p < 0.01; Al (Formula presented.) : ICC = 0.90, 95% CI: 0.84–0.94, p < 0.01) and interoperator reproducibility (PWV: ICC = 0.98, 95% CI: 0.93–1.00, p < 0.01; Al (Formula presented.) : ICC = 0.93, 95% CI: 0.69–0.98, p < 0.01). Measurements were repeated 1 week apart and showed good reproducibility (PWV: ICC = 0.77, 95% CI: 0.61–0.87, p ≤ 0.01; Al (Formula presented.) : ICC = 0.73, 95% CI: 0.73–0.86, p < 0.01). Conclusion: PWV and Al (Formula presented.) demonstrate excellent repeatability and good reproducibility. Considering these variables are noninvasive and easy-to-measure, arterial function assessment may have a role in routine clinical practice to facilitate risk stratification in cardiovascular diseases.",

keywords = "arterial function, augmentation index, pulse wave velocity, reliability",

author = "Russell, {Sophie L.} and Mushidur Rahman and Steward, {Charles James} and Harwood, {Amy Elizabeth} and Gordon McGregor and Prithwish Banerjee and Nduka Okwose and Djordje Jakovljevic",

year = "2024",

month = oct,

day = "28",

doi = "10.1002/hsr2.70155",

language = "English",

volume = "7",

journal = "Health Science Reports",

issn = "2398-8835",

publisher = "Wiley",

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T1 - Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function

AU - Russell, Sophie L.

AU - Rahman, Mushidur

AU - Steward, Charles James

AU - Harwood, Amy Elizabeth

AU - McGregor, Gordon

AU - Banerjee, Prithwish

AU - Okwose, Nduka

AU - Jakovljevic, Djordje

PY - 2024/10/28

Y1 - 2024/10/28

N2 - Background and Aims: Arterial function (specifically arterial stiffness) is an important cardiovascular risk factor. Pulse wave velocity (PWV) and augmentation index (Al (Formula presented.)) are established indicators of arterial function. The present study aimed to evaluate the repeatability and reproducibility of PWV and Al (Formula presented.) in healthy individuals. Methods: Forty healthy participants (age 33 ± 11 years, 17 females) underwent resting supine PWV and Al (Formula presented.) assessments. Measurements were made in triplicate and repeated 1 week apart. Al (Formula presented.) was measured by brachial occlusion and PWV was measured from the carotid artery to the femoral artery via the tonometer-oscillometric method. Repeatability and reproducibility were assessed using the intraclass correlation coefficient (ICC). Interoperator reproducibility was performed on 10 participants. Results: The average values for week-to-week visits for PWV and Al (Formula presented.) were 6.20 ± 0.91 versus 6.13 ± 0.91 ms −1 and 14.0 ± 11.8 versus 16.3 ± 12.2% respectively. For same-day measurements, both PWV and Al (Formula presented.) showed excellent repeatability (PWV: ICC = 0.96, 95% CI: 0.92–0.98, p < 0.01; Al (Formula presented.) : ICC = 0.90, 95% CI: 0.84–0.94, p < 0.01) and interoperator reproducibility (PWV: ICC = 0.98, 95% CI: 0.93–1.00, p < 0.01; Al (Formula presented.) : ICC = 0.93, 95% CI: 0.69–0.98, p < 0.01). Measurements were repeated 1 week apart and showed good reproducibility (PWV: ICC = 0.77, 95% CI: 0.61–0.87, p ≤ 0.01; Al (Formula presented.) : ICC = 0.73, 95% CI: 0.73–0.86, p < 0.01). Conclusion: PWV and Al (Formula presented.) demonstrate excellent repeatability and good reproducibility. Considering these variables are noninvasive and easy-to-measure, arterial function assessment may have a role in routine clinical practice to facilitate risk stratification in cardiovascular diseases.

AB - Background and Aims: Arterial function (specifically arterial stiffness) is an important cardiovascular risk factor. Pulse wave velocity (PWV) and augmentation index (Al (Formula presented.)) are established indicators of arterial function. The present study aimed to evaluate the repeatability and reproducibility of PWV and Al (Formula presented.) in healthy individuals. Methods: Forty healthy participants (age 33 ± 11 years, 17 females) underwent resting supine PWV and Al (Formula presented.) assessments. Measurements were made in triplicate and repeated 1 week apart. Al (Formula presented.) was measured by brachial occlusion and PWV was measured from the carotid artery to the femoral artery via the tonometer-oscillometric method. Repeatability and reproducibility were assessed using the intraclass correlation coefficient (ICC). Interoperator reproducibility was performed on 10 participants. Results: The average values for week-to-week visits for PWV and Al (Formula presented.) were 6.20 ± 0.91 versus 6.13 ± 0.91 ms −1 and 14.0 ± 11.8 versus 16.3 ± 12.2% respectively. For same-day measurements, both PWV and Al (Formula presented.) showed excellent repeatability (PWV: ICC = 0.96, 95% CI: 0.92–0.98, p < 0.01; Al (Formula presented.) : ICC = 0.90, 95% CI: 0.84–0.94, p < 0.01) and interoperator reproducibility (PWV: ICC = 0.98, 95% CI: 0.93–1.00, p < 0.01; Al (Formula presented.) : ICC = 0.93, 95% CI: 0.69–0.98, p < 0.01). Measurements were repeated 1 week apart and showed good reproducibility (PWV: ICC = 0.77, 95% CI: 0.61–0.87, p ≤ 0.01; Al (Formula presented.) : ICC = 0.73, 95% CI: 0.73–0.86, p < 0.01). Conclusion: PWV and Al (Formula presented.) demonstrate excellent repeatability and good reproducibility. Considering these variables are noninvasive and easy-to-measure, arterial function assessment may have a role in routine clinical practice to facilitate risk stratification in cardiovascular diseases.

KW - arterial function

KW - augmentation index

KW - pulse wave velocity

KW - reliability

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DO - 10.1002/hsr2.70155

M3 - Article

C2 - 39474348

SN - 2398-8835

VL - 7

JO - Health Science Reports

JF - Health Science Reports

IS - 11

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ER -

Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function

Abstract

Data Availability Statement

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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