Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes

Sofia I Pascu; Philip A Waghorn; Timothy D Conry; Bonita Lin; Helen M Betts; Jonathan R Dilworth; Robert B Sim; Grant C Churchill; Franklin I Aigbirhio; John E Warren

doi:10.1039/b802806k

Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes

Sofia I Pascu, Philip A Waghorn, Timothy D Conry, Bonita Lin, Helen M Betts, Jonathan R Dilworth, Robert B Sim, Grant C Churchill, Franklin I Aigbirhio, John E Warren

Department of Chemistry

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79 Citations (SciVal)

Abstract

We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.

Original language	English
Pages (from-to)	2107-2110
Number of pages	4
Journal	Dalton Transactions
Volume	2008
Issue number	16
Early online date	18 Mar 2008
DOIs	https://doi.org/10.1039/b802806k
Publication status	Published - 28 Apr 2008

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title = "Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes",

abstract = "We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.",

author = "Pascu, \{Sofia I\} and Waghorn, \{Philip A\} and Conry, \{Timothy D\} and Bonita Lin and Betts, \{Helen M\} and Dilworth, \{Jonathan R\} and Sim, \{Robert B\} and Churchill, \{Grant C\} and Aigbirhio, \{Franklin I\} and Warren, \{John E\}",

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language = "English",

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T1 - Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes

AU - Pascu, Sofia I

AU - Waghorn, Philip A

AU - Conry, Timothy D

AU - Lin, Bonita

AU - Betts, Helen M

AU - Dilworth, Jonathan R

AU - Sim, Robert B

AU - Churchill, Grant C

AU - Aigbirhio, Franklin I

AU - Warren, John E

PY - 2008/4/28

Y1 - 2008/4/28

N2 - We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.

AB - We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.

UR - https://www.scopus.com/pages/publications/41849095602

UR - http://dx.doi.org/10.1039/b802806k

U2 - 10.1039/b802806k

DO - 10.1039/b802806k

M3 - Article

SN - 1477-9226

VL - 2008

SP - 2107

EP - 2110

JO - Dalton Transactions

JF - Dalton Transactions

IS - 16

ER -

Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes

Abstract

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