Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes

Sofia I Pascu, Philip A Waghorn, Timothy D Conry, Bonita Lin, Helen M Betts, Jonathan R Dilworth, Robert B Sim, Grant C Churchill, Franklin I Aigbirhio, John E Warren

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67 Citations (Scopus)

Abstract

We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.
Original languageEnglish
Pages (from-to)2107-2110
Number of pages4
JournalDalton Transactions
Volume2008
Issue number16
Early online date18 Mar 2008
DOIs
Publication statusPublished - 28 Apr 2008

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    Pascu, S. I., Waghorn, P. A., Conry, T. D., Lin, B., Betts, H. M., Dilworth, J. R., Sim, R. B., Churchill, G. C., Aigbirhio, F. I., & Warren, J. E. (2008). Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes. Dalton Transactions, 2008(16), 2107-2110. https://doi.org/10.1039/b802806k