Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes

Sofia I Pascu, Philip A Waghorn, Timothy D Conry, Bonita Lin, Helen M Betts, Jonathan R Dilworth, Robert B Sim, Grant C Churchill, Franklin I Aigbirhio, John E Warren

Research output: Contribution to journalArticlepeer-review

76 Citations (SciVal)

Abstract

We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.
Original languageEnglish
Pages (from-to)2107-2110
Number of pages4
JournalDalton Transactions
Volume2008
Issue number16
Early online date18 Mar 2008
DOIs
Publication statusPublished - 28 Apr 2008

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