Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes

Sofia I Pascu, Philip A Waghorn, Timothy D Conry, Bonita Lin, Helen M Betts, Jonathan R Dilworth, Robert B Sim, Grant C Churchill, Franklin I Aigbirhio, John E Warren

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66 Citations (Scopus)

Abstract

We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.
Original languageEnglish
Pages (from-to)2107-2110
Number of pages4
JournalDalton Transactions
Volume2008
Issue number16
Early online date18 Mar 2008
DOIs
Publication statusPublished - 28 Apr 2008

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Thiosemicarbazones
Mitochondria
Cell death
Cisplatin
Zinc
Fluorescence
Ligands
Imaging techniques

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Pascu, S. I., Waghorn, P. A., Conry, T. D., Lin, B., Betts, H. M., Dilworth, J. R., ... Warren, J. E. (2008). Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes. Dalton Transactions, 2008(16), 2107-2110. https://doi.org/10.1039/b802806k

Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes. / Pascu, Sofia I; Waghorn, Philip A; Conry, Timothy D; Lin, Bonita; Betts, Helen M; Dilworth, Jonathan R; Sim, Robert B; Churchill, Grant C; Aigbirhio, Franklin I; Warren, John E.

In: Dalton Transactions, Vol. 2008, No. 16, 28.04.2008, p. 2107-2110.

Research output: Contribution to journalArticle

Pascu, SI, Waghorn, PA, Conry, TD, Lin, B, Betts, HM, Dilworth, JR, Sim, RB, Churchill, GC, Aigbirhio, FI & Warren, JE 2008, 'Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes', Dalton Transactions, vol. 2008, no. 16, pp. 2107-2110. https://doi.org/10.1039/b802806k
Pascu, Sofia I ; Waghorn, Philip A ; Conry, Timothy D ; Lin, Bonita ; Betts, Helen M ; Dilworth, Jonathan R ; Sim, Robert B ; Churchill, Grant C ; Aigbirhio, Franklin I ; Warren, John E. / Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes. In: Dalton Transactions. 2008 ; Vol. 2008, No. 16. pp. 2107-2110.
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