C/EBP alpha and C/EBP beta are markers of early liver development

A Westmacott, Z D Burke, G Oliver, J M W Slack, D Tosh

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Pancreatic cells can be converted to hepatocytes by overexpression of C/EBP beta (Shen, C-N, Slack, J.M.W. and Tosh, D., 2000. Molecular basis of transdifferentiation of pancreas to liver. Nature Cell Biology2: 879-887). This suggested that expression of one or more C/EBP factors may distinguish liver and pancreas in early development. We have now studied the early expression of C/EBP alpha and C/EBP beta in the mouse embryo and show that both are expressed exclusively in the early liver bud and not in the pancreatic buds. Their expression is identical to that of hepatocyte nuclear factor 4 (HNF4), another key hepatic transcription factor and alpha-fetoprotein (AFP), a differentiation product characteristic of immature hepatocytes. Both are complementary to the early expression of Pdx1, a key pancreatic transcription factor. These results are consistent with the idea that C/EBP factors are master regulators for liver development.
Original languageEnglish
Pages (from-to)653-657
Number of pages5
JournalInternational Journal of Developmental Biology
Volume50
Issue number7
DOIs
Publication statusPublished - 2006

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CCAAT-Enhancer-Binding Protein-alpha
CCAAT-Enhancer-Binding Protein-beta
Liver
Pancreas
Hepatocytes
Hepatocyte Nuclear Factor 4
Transcription Factors
alpha-Fetoproteins
Embryonic Structures

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C/EBP alpha and C/EBP beta are markers of early liver development. / Westmacott, A; Burke, Z D; Oliver, G; Slack, J M W; Tosh, D.

In: International Journal of Developmental Biology, Vol. 50, No. 7, 2006, p. 653-657.

Research output: Contribution to journalArticle

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