Catalytic SNAr of unactivated aryl chlorides

James W. Walton; Jonathan M J Williams

doi:10.1039/c4cc07116f

Catalytic S_NAr of unactivated aryl chlorides

James W. Walton, Jonathan M J Williams

Durham University

Research output: Contribution to journal › Article › peer-review

37 Citations (SciVal)

Abstract

We present nucleophilic aromatic substitution of unsubstituted aryl chlorides via a mechanism that is catalytic in [CpRu(p-cymene)]PF₆ and involves a Ru(η⁶-arylchloride) intermediate. From the spectroscopic evidence we infer that arene exchange is the rate limiting step in this process and develop several new Ru(ii) complexes that lower the activation barrier to arene exchange.

Original language	English
Pages (from-to)	2786-2789
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	14
Early online date	6 Oct 2014
DOIs	https://doi.org/10.1039/c4cc07116f
Publication status	Published - 18 Feb 2015

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10.1039/c4cc07116f

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title = "Catalytic SNAr of unactivated aryl chlorides",

abstract = "We present nucleophilic aromatic substitution of unsubstituted aryl chlorides via a mechanism that is catalytic in [CpRu(p-cymene)]PF6 and involves a Ru(η6-arylchloride) intermediate. From the spectroscopic evidence we infer that arene exchange is the rate limiting step in this process and develop several new Ru(ii) complexes that lower the activation barrier to arene exchange.",

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AU - Williams, Jonathan M J

PY - 2015/2/18

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N2 - We present nucleophilic aromatic substitution of unsubstituted aryl chlorides via a mechanism that is catalytic in [CpRu(p-cymene)]PF6 and involves a Ru(η6-arylchloride) intermediate. From the spectroscopic evidence we infer that arene exchange is the rate limiting step in this process and develop several new Ru(ii) complexes that lower the activation barrier to arene exchange.

AB - We present nucleophilic aromatic substitution of unsubstituted aryl chlorides via a mechanism that is catalytic in [CpRu(p-cymene)]PF6 and involves a Ru(η6-arylchloride) intermediate. From the spectroscopic evidence we infer that arene exchange is the rate limiting step in this process and develop several new Ru(ii) complexes that lower the activation barrier to arene exchange.

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DO - 10.1039/c4cc07116f

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ER -

Catalytic S_NAr of unactivated aryl chlorides

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Catalytic SNAr of unactivated aryl chlorides

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Catalytic S_NAr of unactivated aryl chlorides