Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

Andrew Paterson; Sahra  St. John-Campbell; Mary Mahon; N J Press; Christopher Frost

doi:10.1039/C5CC03951G

Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

Andrew Paterson, Sahra St. John-Campbell , Mary Mahon, N J Press, Christopher Frost

Novartis Institutes for BioMedical Research, Novartis Campus

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Abstract

A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.

Original language	English
Pages (from-to)	12807-12810
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	64
Early online date	6 Jul 2015
DOIs	https://doi.org/10.1039/C5CC03951G
Publication status	Published - 18 Aug 2015

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10.1039/C5CC03951G

Catalytic meta-selective C-H functionalizationFinal published version, 2.23 MBLicence: CC BY

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title = "Catalytic meta-selective C–H functionalization to construct quaternary carbon centres",

abstract = "A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.",

author = "Andrew Paterson and \{St. John-Campbell\}, Sahra and Mary Mahon and Press, \{N J\} and Christopher Frost",

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AU - Paterson, Andrew

AU - St. John-Campbell , Sahra

AU - Mahon, Mary

AU - Press, N J

AU - Frost, Christopher

PY - 2015/8/18

Y1 - 2015/8/18

N2 - A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.

AB - A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.

UR - http://dx.doi.org/10.1039/C5CC03951G

UR - http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC03951G#!divAbstract

U2 - 10.1039/C5CC03951G

DO - 10.1039/C5CC03951G

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VL - 51

SP - 12807

EP - 12810

JO - Chemical Communications

JF - Chemical Communications

IS - 64

ER -

Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

Abstract

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