Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

Andrew Paterson, Sahra St. John-Campbell , Mary Mahon, N J Press, Christopher Frost

Research output: Contribution to journalArticle

82 Citations (Scopus)
83 Downloads (Pure)

Abstract

A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.
Original languageEnglish
Pages (from-to)12807-12810
Number of pages4
JournalChemical Communications
Volume51
Issue number64
Early online date6 Jul 2015
DOIs
Publication statusPublished - 18 Aug 2015

Fingerprint

Carbon
Chemical activation
2-phenylpyridine

Cite this

Catalytic meta-selective C–H functionalization to construct quaternary carbon centres. / Paterson, Andrew; St. John-Campbell , Sahra ; Mahon, Mary; Press, N J; Frost, Christopher.

In: Chemical Communications, Vol. 51, No. 64, 18.08.2015, p. 12807-12810.

Research output: Contribution to journalArticle

Paterson, Andrew ; St. John-Campbell , Sahra ; Mahon, Mary ; Press, N J ; Frost, Christopher. / Catalytic meta-selective C–H functionalization to construct quaternary carbon centres. In: Chemical Communications. 2015 ; Vol. 51, No. 64. pp. 12807-12810.
@article{7f724ce5e65c4e76b1d0ab6693e26bd6,
title = "Catalytic meta-selective C–H functionalization to construct quaternary carbon centres",
abstract = "A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.",
author = "Andrew Paterson and {St. John-Campbell}, Sahra and Mary Mahon and Press, {N J} and Christopher Frost",
year = "2015",
month = "8",
day = "18",
doi = "10.1039/C5CC03951G",
language = "English",
volume = "51",
pages = "12807--12810",
journal = "Chemical communications (Cambridge, England)",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "64",

}

TY - JOUR

T1 - Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

AU - Paterson, Andrew

AU - St. John-Campbell , Sahra

AU - Mahon, Mary

AU - Press, N J

AU - Frost, Christopher

PY - 2015/8/18

Y1 - 2015/8/18

N2 - A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.

AB - A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.

UR - http://dx.doi.org/10.1039/C5CC03951G

UR - http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC03951G#!divAbstract

U2 - 10.1039/C5CC03951G

DO - 10.1039/C5CC03951G

M3 - Article

VL - 51

SP - 12807

EP - 12810

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

SN - 1359-7345

IS - 64

ER -