A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.
Paterson, A., St. John-Campbell , S., Mahon, M., Press, N. J., & Frost, C. (2015). Catalytic meta-selective C–H functionalization to construct quaternary carbon centres. Chemical Communications, 51(64), 12807-12810. https://doi.org/10.1039/C5CC03951G