Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

Andrew Paterson, Sahra St. John-Campbell , Mary Mahon, N J Press, Christopher Frost

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A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.
Original languageEnglish
Pages (from-to)12807-12810
Number of pages4
JournalChemical Communications
Issue number64
Early online date6 Jul 2015
Publication statusPublished - 18 Aug 2015


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