Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

Andrew Paterson; Sahra  St. John-Campbell; Mary Mahon; N J Press; Christopher Frost

doi:10.1039/C5CC03951G

Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

Andrew Paterson, Sahra St. John-Campbell , Mary Mahon, N J Press, Christopher Frost

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Abstract

A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.

Original language	English
Pages (from-to)	12807-12810
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	64
Early online date	6 Jul 2015
DOIs	https://doi.org/10.1039/C5CC03951G
Publication status	Published - 18 Aug 2015

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Paterson, A., St. John-Campbell , S., Mahon, M., Press, N. J., & Frost, C. (2015). Catalytic meta-selective C–H functionalization to construct quaternary carbon centres. Chemical Communications, 51(64), 12807-12810. https://doi.org/10.1039/C5CC03951G

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AU - Frost, Christopher

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AB - A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.

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Access to Document

10.1039/C5CC03951G

Catalytic meta-selective C-H functionalizationFinal published version, 2.23 MBLicence: CC BY