Catalytic acylation of amines with aldehydes or aldoximes

C L Allen, Simge Davulcu, Jonathan Williams

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

The simple nickel salt NiCl2 center dot 6H(2)O catalyzes the coupling of aldoximes with amines to give secondary or tertiary amide products. The aldoxime can be prepared in situ from the corresponding aldehyde. The use of O-18-labeled oximes has allowed insight into the mechanism of this reaction.
Original languageEnglish
Pages (from-to)5096-5099
Number of pages4
JournalOrganic Letters
Volume12
Issue number22
DOIs
Publication statusPublished - 2010

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