Catalytic acylation of amines with aldehydes or aldoximes

C L Allen; Simge Davulcu; Jonathan Williams

doi:10.1021/ol101978h

Catalytic acylation of amines with aldehydes or aldoximes

C L Allen, Simge Davulcu, Jonathan Williams

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

115 Citations (SciVal)

Abstract

The simple nickel salt NiCl2 center dot 6H(2)O catalyzes the coupling of aldoximes with amines to give secondary or tertiary amide products. The aldoxime can be prepared in situ from the corresponding aldehyde. The use of O-18-labeled oximes has allowed insight into the mechanism of this reaction.

Original language	English
Pages (from-to)	5096-5099
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	22
DOIs	https://doi.org/10.1021/ol101978h
Publication status	Published - 2010

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10.1021/ol101978h

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title = "Catalytic acylation of amines with aldehydes or aldoximes",

abstract = "The simple nickel salt NiCl2 center dot 6H(2)O catalyzes the coupling of aldoximes with amines to give secondary or tertiary amide products. The aldoxime can be prepared in situ from the corresponding aldehyde. The use of O-18-labeled oximes has allowed insight into the mechanism of this reaction.",

author = "Allen, {C L} and Simge Davulcu and Jonathan Williams",

year = "2010",

doi = "10.1021/ol101978h",

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AU - Allen, C L

AU - Davulcu, Simge

AU - Williams, Jonathan

PY - 2010

Y1 - 2010

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AB - The simple nickel salt NiCl2 center dot 6H(2)O catalyzes the coupling of aldoximes with amines to give secondary or tertiary amide products. The aldoxime can be prepared in situ from the corresponding aldehyde. The use of O-18-labeled oximes has allowed insight into the mechanism of this reaction.

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UR - http://dx.doi.org/10.1021/ol101978h

U2 - 10.1021/ol101978h

DO - 10.1021/ol101978h

M3 - Article

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VL - 12

SP - 5096

EP - 5099

JO - Organic Letters

JF - Organic Letters

IS - 22

ER -

Catalytic acylation of amines with aldehydes or aldoximes

Abstract

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