Cardioprotection by 6-gingerol in diabetic rats

Hany M. El-Bassossy, Ahmed A. Elberry, Salah A. Ghareib, Ahmad Azhar, Zainey Mohammed Banjar, Malcolm L Watson

Research output: Contribution to journalArticle

5 Citations (Scopus)
129 Downloads (Pure)

Abstract

The current study was conducted to evaluate the effect of 6-gingerol (6G) on cardiac complications in streptozotocin (STZ)-induced diabetic (DM) rats. STZ-induced DM rats (single 50 mg/kg i.p. injection, 15 days prior to drug treatment) or time-matched controls were treated with 6G (75 mg/day route orally). After a further 8 weeks, blood was collected for biochemical analysis and 8-isoprostenol was measured in urine. Cardiac hemodynamics and ECG was assessed. 6G significantly attenuated the increased level of blood glucose in diabetic rats and improved cardiac hemodynamics in including RR interval, max dP/dt, min dP/dt and Tau. In addition, 6G alleviated the elevated ST segment, T amplitude and R amplitude with no significant effect on disturbed levels of adiponectin, TGF-β or 8-isoprostenol induced by diabetes. The results showed that treatment with 6G has an ameliorative effect on cardiac dysfunction induced by diabetes. Which may be not related to its potential antioxidant effect.
Original languageEnglish
Pages (from-to)908-914
JournalBiochemical and Biophysical Research Communications
Volume477
Issue number4
Early online date1 Jul 2016
DOIs
Publication statusPublished - 2 Sep 2016

Fingerprint

Rats
Hemodynamics
Streptozocin
Medical problems
Drug therapy
Adiponectin
Electrocardiography
Transforming Growth Factor beta
Blood Glucose
Blood
Antioxidants
gingerol
Urine
Injections
Therapeutics
Pharmaceutical Preparations

Cite this

El-Bassossy, H. M., Elberry, A. A., Ghareib, S. A., Azhar, A., Banjar, Z. M., & Watson, M. L. (2016). Cardioprotection by 6-gingerol in diabetic rats. Biochemical and Biophysical Research Communications, 477(4), 908-914. https://doi.org/10.1016/j.bbrc.2016.06.157

Cardioprotection by 6-gingerol in diabetic rats. / El-Bassossy, Hany M.; Elberry, Ahmed A.; Ghareib, Salah A.; Azhar, Ahmad; Banjar, Zainey Mohammed; Watson, Malcolm L.

In: Biochemical and Biophysical Research Communications, Vol. 477, No. 4, 02.09.2016, p. 908-914.

Research output: Contribution to journalArticle

El-Bassossy, HM, Elberry, AA, Ghareib, SA, Azhar, A, Banjar, ZM & Watson, ML 2016, 'Cardioprotection by 6-gingerol in diabetic rats', Biochemical and Biophysical Research Communications, vol. 477, no. 4, pp. 908-914. https://doi.org/10.1016/j.bbrc.2016.06.157
El-Bassossy, Hany M. ; Elberry, Ahmed A. ; Ghareib, Salah A. ; Azhar, Ahmad ; Banjar, Zainey Mohammed ; Watson, Malcolm L. / Cardioprotection by 6-gingerol in diabetic rats. In: Biochemical and Biophysical Research Communications. 2016 ; Vol. 477, No. 4. pp. 908-914.
@article{e1820e5d7fe046dbb39b6a9a248448db,
title = "Cardioprotection by 6-gingerol in diabetic rats",
abstract = "The current study was conducted to evaluate the effect of 6-gingerol (6G) on cardiac complications in streptozotocin (STZ)-induced diabetic (DM) rats. STZ-induced DM rats (single 50 mg/kg i.p. injection, 15 days prior to drug treatment) or time-matched controls were treated with 6G (75 mg/day route orally). After a further 8 weeks, blood was collected for biochemical analysis and 8-isoprostenol was measured in urine. Cardiac hemodynamics and ECG was assessed. 6G significantly attenuated the increased level of blood glucose in diabetic rats and improved cardiac hemodynamics in including RR interval, max dP/dt, min dP/dt and Tau. In addition, 6G alleviated the elevated ST segment, T amplitude and R amplitude with no significant effect on disturbed levels of adiponectin, TGF-β or 8-isoprostenol induced by diabetes. The results showed that treatment with 6G has an ameliorative effect on cardiac dysfunction induced by diabetes. Which may be not related to its potential antioxidant effect.",
author = "El-Bassossy, {Hany M.} and Elberry, {Ahmed A.} and Ghareib, {Salah A.} and Ahmad Azhar and Banjar, {Zainey Mohammed} and Watson, {Malcolm L}",
year = "2016",
month = "9",
day = "2",
doi = "10.1016/j.bbrc.2016.06.157",
language = "English",
volume = "477",
pages = "908--914",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Elsevier Academic Press Inc",
number = "4",

}

TY - JOUR

T1 - Cardioprotection by 6-gingerol in diabetic rats

AU - El-Bassossy, Hany M.

AU - Elberry, Ahmed A.

AU - Ghareib, Salah A.

AU - Azhar, Ahmad

AU - Banjar, Zainey Mohammed

AU - Watson, Malcolm L

PY - 2016/9/2

Y1 - 2016/9/2

N2 - The current study was conducted to evaluate the effect of 6-gingerol (6G) on cardiac complications in streptozotocin (STZ)-induced diabetic (DM) rats. STZ-induced DM rats (single 50 mg/kg i.p. injection, 15 days prior to drug treatment) or time-matched controls were treated with 6G (75 mg/day route orally). After a further 8 weeks, blood was collected for biochemical analysis and 8-isoprostenol was measured in urine. Cardiac hemodynamics and ECG was assessed. 6G significantly attenuated the increased level of blood glucose in diabetic rats and improved cardiac hemodynamics in including RR interval, max dP/dt, min dP/dt and Tau. In addition, 6G alleviated the elevated ST segment, T amplitude and R amplitude with no significant effect on disturbed levels of adiponectin, TGF-β or 8-isoprostenol induced by diabetes. The results showed that treatment with 6G has an ameliorative effect on cardiac dysfunction induced by diabetes. Which may be not related to its potential antioxidant effect.

AB - The current study was conducted to evaluate the effect of 6-gingerol (6G) on cardiac complications in streptozotocin (STZ)-induced diabetic (DM) rats. STZ-induced DM rats (single 50 mg/kg i.p. injection, 15 days prior to drug treatment) or time-matched controls were treated with 6G (75 mg/day route orally). After a further 8 weeks, blood was collected for biochemical analysis and 8-isoprostenol was measured in urine. Cardiac hemodynamics and ECG was assessed. 6G significantly attenuated the increased level of blood glucose in diabetic rats and improved cardiac hemodynamics in including RR interval, max dP/dt, min dP/dt and Tau. In addition, 6G alleviated the elevated ST segment, T amplitude and R amplitude with no significant effect on disturbed levels of adiponectin, TGF-β or 8-isoprostenol induced by diabetes. The results showed that treatment with 6G has an ameliorative effect on cardiac dysfunction induced by diabetes. Which may be not related to its potential antioxidant effect.

UR - http://dx.doi.org/10.1016/j.bbrc.2016.06.157

U2 - 10.1016/j.bbrc.2016.06.157

DO - 10.1016/j.bbrc.2016.06.157

M3 - Article

VL - 477

SP - 908

EP - 914

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 4

ER -