Cardiac output is improved in rats myocardial infraction by enhancement of respiratory sinus arrhythmia

Erin O'Callaghan, Renata Lataro, Le Zhao, Alona Ben Tal, Alain Nogaret, Julian Paton

Research output: Contribution to journalMeeting abstract

Abstract

Respiratory sinus arrhythmia (RSA) is the physiological modulation of heart rate during respiration. Whilst its physiological function is debated, recent mathematical modelling predicts that RSA saves cardiac energy. Heart failure is associated with a loss of RSA. We aimed to test whether RSA would improve cardiac function in rats 3 days after left ascending coronary artery ligation (post-MI). Cardiac dysfunction was indicated by infarct size (43±7% of left ventricle) and prolonged systole duration accompanied by reduced peak aortic flow compared to SHAM rats. We built and used a novel central pattern generator (CPG) that, utilizing real-time diaphragm electromyogram input, generated RSA via respiratory phase-locked stimulus output to the right cervical vagus nerve. In post-MI rats, RSA enhancement caused a 12±3% increase in stroke volume, irrespective of the RSA amplitude. Tonic VNS at matched average heart rate increased stroke volume to a similar degree (8±1%, P =0.25 compared to RSA) (n = 7). Despite the increase in stroke volume, myocardial lactate concentrations were unchanged after 45 min of RSA (29±7bpm) or tonic VNS treatment (P = 0.35, One-way ANOVA). Using a novel CPG device we have demonstrated that, in an acute setting, RSA increases stroke volume in post-MI rats. British Heart Foundation and Fundação de Amparo à Pesquisa do Estado de São Paulo
LanguageEnglish
Article number1043.3
Number of pages1
JournalFASEB Journal
Volume2015
Issue number29, 1 Supplement
StatusPublished - 1 Apr 2015

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Cardiac Output
Rats
Stroke Volume
Central Pattern Generators
Diaphragms
Analysis of variance (ANOVA)
Lactic Acid
Modulation
Heart Rate
Respiratory Sinus Arrhythmia
Vagus Nerve
Systole
Electromyography
Diaphragm
Heart Ventricles
Ligation
Coronary Vessels
Analysis of Variance
Respiration
Heart Failure

Cite this

O'Callaghan, E., Lataro, R., Zhao, L., Ben Tal, A., Nogaret, A., & Paton, J. (2015). Cardiac output is improved in rats myocardial infraction by enhancement of respiratory sinus arrhythmia. FASEB Journal, 2015(29, 1 Supplement), [1043.3].

Cardiac output is improved in rats myocardial infraction by enhancement of respiratory sinus arrhythmia. / O'Callaghan, Erin; Lataro, Renata; Zhao, Le; Ben Tal, Alona; Nogaret, Alain; Paton, Julian.

In: FASEB Journal, Vol. 2015, No. 29, 1 Supplement, 1043.3, 01.04.2015.

Research output: Contribution to journalMeeting abstract

O'Callaghan, E, Lataro, R, Zhao, L, Ben Tal, A, Nogaret, A & Paton, J 2015, 'Cardiac output is improved in rats myocardial infraction by enhancement of respiratory sinus arrhythmia', FASEB Journal, vol. 2015, no. 29, 1 Supplement, 1043.3.
O'Callaghan E, Lataro R, Zhao L, Ben Tal A, Nogaret A, Paton J. Cardiac output is improved in rats myocardial infraction by enhancement of respiratory sinus arrhythmia. FASEB Journal. 2015 Apr 1;2015(29, 1 Supplement). 1043.3.
O'Callaghan, Erin ; Lataro, Renata ; Zhao, Le ; Ben Tal, Alona ; Nogaret, Alain ; Paton, Julian. / Cardiac output is improved in rats myocardial infraction by enhancement of respiratory sinus arrhythmia. In: FASEB Journal. 2015 ; Vol. 2015, No. 29, 1 Supplement.
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