Cannabis Dampens the Effects of Music in Brain Regions Sensitive to Reward and Emotion

Tom P Freeman, Rebecca A Pope, Matthew B Wall, James A Bisby, Maartje Luijten, Chandni Hindocha, Claire Mokrysz, Will Lawn, Abigail Moss, Michael A P Bloomfield, Celia J A Morgan, David J Nutt, H Valerie Curran

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Despite the current shift towards permissive cannabis policies, few studies have investigated the pleasurable effects users seek. Here, we investigate the effects of cannabis on listening to music, a rewarding activity that frequently occurs in the context of recreational cannabis use. We additionally tested how these effects are influenced by cannabidiol, which may offset cannabis-related harms. Methods: Across 3 sessions, 16 cannabis users inhaled cannabis with cannabidiol, cannabis without cannabidiol, and placebo. We compared their response to music relative to control excerpts of scrambled sound during functional Magnetic Resonance Imaging within regions identified in a meta-analysis of music-evoked reward and emotion. All results were False Discovery Rate corrected (P < .05). Results: Compared with placebo, cannabis without cannabidiol dampened response to music in bilateral auditory cortex (right: P = .005, left: P = .008), right hippocampus/parahippocampal gyrus (P = .025), right amygdala (P = .025), and right ventral striatum (P = .033). Across all sessions, the effects of music in this ventral striatal region correlated with pleasure ratings (P = .002) and increased functional connectivity with auditory cortex (right: P < .001, left: P < .001), supporting its involvement in music reward. Functional connectivity between right ventral striatum and auditory cortex was increased by cannabidiol (right: P = .003, left: P = .030), and cannabis with cannabidiol did not differ from placebo on any functional Magnetic Resonance Imaging measures. Both types of cannabis increased ratings of wanting to listen to music (P < .002) and enhanced sound perception (P < .001). Conclusions: Cannabis dampens the effects of music in brain regions sensitive to reward and emotion. These effects were offset by a key cannabis constituent, cannabidol.

Original languageEnglish
Pages (from-to)21-32
Number of pages12
JournalInternational Journal of Neuropsychopharmacology
Volume21
Issue number1
Early online date2 Sep 2017
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Cannabis
Music
Reward
Emotions
Cannabidiol
Brain
Auditory Cortex
Placebos
Magnetic Resonance Imaging
Corpus Striatum
Parahippocampal Gyrus
Pleasure
Amygdala
Meta-Analysis
Hippocampus

Keywords

  • cannabis
  • emotion
  • music
  • pleasure
  • reward

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Cannabis Dampens the Effects of Music in Brain Regions Sensitive to Reward and Emotion. / Freeman, Tom P; Pope, Rebecca A; Wall, Matthew B; Bisby, James A; Luijten, Maartje; Hindocha, Chandni; Mokrysz, Claire; Lawn, Will; Moss, Abigail; Bloomfield, Michael A P; Morgan, Celia J A; Nutt, David J; Curran, H Valerie.

In: International Journal of Neuropsychopharmacology, Vol. 21, No. 1, 01.01.2018, p. 21-32.

Research output: Contribution to journalArticle

Freeman, TP, Pope, RA, Wall, MB, Bisby, JA, Luijten, M, Hindocha, C, Mokrysz, C, Lawn, W, Moss, A, Bloomfield, MAP, Morgan, CJA, Nutt, DJ & Curran, HV 2018, 'Cannabis Dampens the Effects of Music in Brain Regions Sensitive to Reward and Emotion', International Journal of Neuropsychopharmacology, vol. 21, no. 1, pp. 21-32. https://doi.org/10.1093/ijnp/pyx082
Freeman, Tom P ; Pope, Rebecca A ; Wall, Matthew B ; Bisby, James A ; Luijten, Maartje ; Hindocha, Chandni ; Mokrysz, Claire ; Lawn, Will ; Moss, Abigail ; Bloomfield, Michael A P ; Morgan, Celia J A ; Nutt, David J ; Curran, H Valerie. / Cannabis Dampens the Effects of Music in Brain Regions Sensitive to Reward and Emotion. In: International Journal of Neuropsychopharmacology. 2018 ; Vol. 21, No. 1. pp. 21-32.
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abstract = "Background: Despite the current shift towards permissive cannabis policies, few studies have investigated the pleasurable effects users seek. Here, we investigate the effects of cannabis on listening to music, a rewarding activity that frequently occurs in the context of recreational cannabis use. We additionally tested how these effects are influenced by cannabidiol, which may offset cannabis-related harms. Methods: Across 3 sessions, 16 cannabis users inhaled cannabis with cannabidiol, cannabis without cannabidiol, and placebo. We compared their response to music relative to control excerpts of scrambled sound during functional Magnetic Resonance Imaging within regions identified in a meta-analysis of music-evoked reward and emotion. All results were False Discovery Rate corrected (P < .05). Results: Compared with placebo, cannabis without cannabidiol dampened response to music in bilateral auditory cortex (right: P = .005, left: P = .008), right hippocampus/parahippocampal gyrus (P = .025), right amygdala (P = .025), and right ventral striatum (P = .033). Across all sessions, the effects of music in this ventral striatal region correlated with pleasure ratings (P = .002) and increased functional connectivity with auditory cortex (right: P < .001, left: P < .001), supporting its involvement in music reward. Functional connectivity between right ventral striatum and auditory cortex was increased by cannabidiol (right: P = .003, left: P = .030), and cannabis with cannabidiol did not differ from placebo on any functional Magnetic Resonance Imaging measures. Both types of cannabis increased ratings of wanting to listen to music (P < .002) and enhanced sound perception (P < .001). Conclusions: Cannabis dampens the effects of music in brain regions sensitive to reward and emotion. These effects were offset by a key cannabis constituent, cannabidol.",
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AU - Pope, Rebecca A

AU - Wall, Matthew B

AU - Bisby, James A

AU - Luijten, Maartje

AU - Hindocha, Chandni

AU - Mokrysz, Claire

AU - Lawn, Will

AU - Moss, Abigail

AU - Bloomfield, Michael A P

AU - Morgan, Celia J A

AU - Nutt, David J

AU - Curran, H Valerie

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N2 - Background: Despite the current shift towards permissive cannabis policies, few studies have investigated the pleasurable effects users seek. Here, we investigate the effects of cannabis on listening to music, a rewarding activity that frequently occurs in the context of recreational cannabis use. We additionally tested how these effects are influenced by cannabidiol, which may offset cannabis-related harms. Methods: Across 3 sessions, 16 cannabis users inhaled cannabis with cannabidiol, cannabis without cannabidiol, and placebo. We compared their response to music relative to control excerpts of scrambled sound during functional Magnetic Resonance Imaging within regions identified in a meta-analysis of music-evoked reward and emotion. All results were False Discovery Rate corrected (P < .05). Results: Compared with placebo, cannabis without cannabidiol dampened response to music in bilateral auditory cortex (right: P = .005, left: P = .008), right hippocampus/parahippocampal gyrus (P = .025), right amygdala (P = .025), and right ventral striatum (P = .033). Across all sessions, the effects of music in this ventral striatal region correlated with pleasure ratings (P = .002) and increased functional connectivity with auditory cortex (right: P < .001, left: P < .001), supporting its involvement in music reward. Functional connectivity between right ventral striatum and auditory cortex was increased by cannabidiol (right: P = .003, left: P = .030), and cannabis with cannabidiol did not differ from placebo on any functional Magnetic Resonance Imaging measures. Both types of cannabis increased ratings of wanting to listen to music (P < .002) and enhanced sound perception (P < .001). Conclusions: Cannabis dampens the effects of music in brain regions sensitive to reward and emotion. These effects were offset by a key cannabis constituent, cannabidol.

AB - Background: Despite the current shift towards permissive cannabis policies, few studies have investigated the pleasurable effects users seek. Here, we investigate the effects of cannabis on listening to music, a rewarding activity that frequently occurs in the context of recreational cannabis use. We additionally tested how these effects are influenced by cannabidiol, which may offset cannabis-related harms. Methods: Across 3 sessions, 16 cannabis users inhaled cannabis with cannabidiol, cannabis without cannabidiol, and placebo. We compared their response to music relative to control excerpts of scrambled sound during functional Magnetic Resonance Imaging within regions identified in a meta-analysis of music-evoked reward and emotion. All results were False Discovery Rate corrected (P < .05). Results: Compared with placebo, cannabis without cannabidiol dampened response to music in bilateral auditory cortex (right: P = .005, left: P = .008), right hippocampus/parahippocampal gyrus (P = .025), right amygdala (P = .025), and right ventral striatum (P = .033). Across all sessions, the effects of music in this ventral striatal region correlated with pleasure ratings (P = .002) and increased functional connectivity with auditory cortex (right: P < .001, left: P < .001), supporting its involvement in music reward. Functional connectivity between right ventral striatum and auditory cortex was increased by cannabidiol (right: P = .003, left: P = .030), and cannabis with cannabidiol did not differ from placebo on any functional Magnetic Resonance Imaging measures. Both types of cannabis increased ratings of wanting to listen to music (P < .002) and enhanced sound perception (P < .001). Conclusions: Cannabis dampens the effects of music in brain regions sensitive to reward and emotion. These effects were offset by a key cannabis constituent, cannabidol.

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