Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal

Chandni Hindocha, Tom P. Freeman, Meryem Grabski, Jack B. Stroud, Holly Crudgington, Alan C. Davies, Ravi K. Das, William Lawn, Celia J.A. Morgan, H. Valerie Curran

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background and Aims: Cannabidiol (CBD), a non-intoxicating cannabinoid found in cannabis, may be a promising novel smoking cessation treatment due to its anxiolytic properties, minimal side effects and research showing that it may modify drug cue salience. We used an experimental medicine approach with dependent cigarette smokers to investigate if (1) overnight nicotine abstinence, compared with satiety, will produce greater attentional bias (AB), higher pleasantness ratings of cigarette-related stimuli and increased craving and withdrawal; and (2) CBD in comparison to placebo, would attenuate AB, pleasantness of cigarette-related stimuli, craving and withdrawal and not produce any side effects. Design: Randomized, double-blind cross-over study with a fixed satiated session followed by two overnight abstinent sessions. Setting: UK laboratory. Participants: Thirty non-treatment-seeking, dependent cigarette smokers recruited from the community. Intervention and comparator: 800 mg oral CBD, or matched placebo (PBO) in a counterbalanced order. Measurements: AB to pictorial tobacco cues was recorded using a visual probe task and an explicit rating task. Withdrawal, craving, side effects, heart rate and blood pressure were assessed repeatedly. Findings: When participants received PBO, tobacco abstinence increased AB (P = 0.001, d = 0.789) compared with satiety. However, CBD reversed this effect, such that automatic AB was directed away from cigarette cues (P = 0.007, d = 0.704) and no longer differed from satiety (P = 0.82). Compared with PBO, CBD also reduced explicit pleasantness of cigarette images (P = 0.011; d = 0.514). Craving (Bayes factor = 7.08) and withdrawal (Bayes factor = 6.95) were unaffected by CBD, but greater in abstinence compared with satiety. Systolic blood pressure decreased under CBD during abstinence. Conclusions: A single 800-mg oral dose of cannabidiol reduced the salience and pleasantness of cigarette cues, compared with placebo, after overnight cigarette abstinence in dependent smokers. Cannabidiol did not influence tobacco craving or withdrawal or any subjectively rated side effects.

Original languageEnglish
Pages (from-to)1696-1705
Number of pages10
JournalAddiction
Volume113
Issue number9
Early online date1 May 2018
DOIs
Publication statusPublished - 2 Aug 2018

Fingerprint

Cannabidiol
Tobacco Products
Tobacco
Cues
Theoretical Models
Placebos
Blood Pressure
Attentional Bias
Withholding Treatment
Cannabinoids
Anti-Anxiety Agents
Smoking Cessation
Cannabis
Nicotine
Cross-Over Studies
Biomedical Research
Heart Rate
Craving

Keywords

  • Abstinence
  • attentional bias
  • cannabidiol
  • cigarette dependence
  • craving
  • withdrawal

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health

Cite this

Hindocha, C., Freeman, T. P., Grabski, M., Stroud, J. B., Crudgington, H., Davies, A. C., ... Curran, H. V. (2018). Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal. Addiction, 113(9), 1696-1705. https://doi.org/10.1111/add.14243

Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal. / Hindocha, Chandni; Freeman, Tom P.; Grabski, Meryem; Stroud, Jack B.; Crudgington, Holly; Davies, Alan C.; Das, Ravi K.; Lawn, William; Morgan, Celia J.A.; Curran, H. Valerie.

In: Addiction, Vol. 113, No. 9, 02.08.2018, p. 1696-1705.

Research output: Contribution to journalArticle

Hindocha, C, Freeman, TP, Grabski, M, Stroud, JB, Crudgington, H, Davies, AC, Das, RK, Lawn, W, Morgan, CJA & Curran, HV 2018, 'Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal', Addiction, vol. 113, no. 9, pp. 1696-1705. https://doi.org/10.1111/add.14243
Hindocha, Chandni ; Freeman, Tom P. ; Grabski, Meryem ; Stroud, Jack B. ; Crudgington, Holly ; Davies, Alan C. ; Das, Ravi K. ; Lawn, William ; Morgan, Celia J.A. ; Curran, H. Valerie. / Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal. In: Addiction. 2018 ; Vol. 113, No. 9. pp. 1696-1705.
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AU - Davies, Alan C.

AU - Das, Ravi K.

AU - Lawn, William

AU - Morgan, Celia J.A.

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N2 - Background and Aims: Cannabidiol (CBD), a non-intoxicating cannabinoid found in cannabis, may be a promising novel smoking cessation treatment due to its anxiolytic properties, minimal side effects and research showing that it may modify drug cue salience. We used an experimental medicine approach with dependent cigarette smokers to investigate if (1) overnight nicotine abstinence, compared with satiety, will produce greater attentional bias (AB), higher pleasantness ratings of cigarette-related stimuli and increased craving and withdrawal; and (2) CBD in comparison to placebo, would attenuate AB, pleasantness of cigarette-related stimuli, craving and withdrawal and not produce any side effects. Design: Randomized, double-blind cross-over study with a fixed satiated session followed by two overnight abstinent sessions. Setting: UK laboratory. Participants: Thirty non-treatment-seeking, dependent cigarette smokers recruited from the community. Intervention and comparator: 800 mg oral CBD, or matched placebo (PBO) in a counterbalanced order. Measurements: AB to pictorial tobacco cues was recorded using a visual probe task and an explicit rating task. Withdrawal, craving, side effects, heart rate and blood pressure were assessed repeatedly. Findings: When participants received PBO, tobacco abstinence increased AB (P = 0.001, d = 0.789) compared with satiety. However, CBD reversed this effect, such that automatic AB was directed away from cigarette cues (P = 0.007, d = 0.704) and no longer differed from satiety (P = 0.82). Compared with PBO, CBD also reduced explicit pleasantness of cigarette images (P = 0.011; d = 0.514). Craving (Bayes factor = 7.08) and withdrawal (Bayes factor = 6.95) were unaffected by CBD, but greater in abstinence compared with satiety. Systolic blood pressure decreased under CBD during abstinence. Conclusions: A single 800-mg oral dose of cannabidiol reduced the salience and pleasantness of cigarette cues, compared with placebo, after overnight cigarette abstinence in dependent smokers. Cannabidiol did not influence tobacco craving or withdrawal or any subjectively rated side effects.

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