cAMP responsive element-binding protein phosphorylation is necessary for perirhinal long-term potentiation and recognition memory

E C Warburton, C P J Glover, Peter V Massey, H Wan, B Johnson, A Bienemann, A Deuschle, J N C Kew, J P Aggleton, Z I Bashir, J Uney, M W Brown

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Abstract

We established the importance of phosphorylation of cAMP responsive element-binding protein (CREB) to both the familiarity discrimination component of long-term recognition memory and plasticity within the perirhinal cortex of the temporal lobe. Adenoviral transduction of perirhinal cortex (and adjacent visual association cortex) with a dominant-negative inhibitor of CREB impaired the preferential exploration of novel over familiar objects at a long (24 h) but not a short (15 min) delay, disrupted the normal reduced activation of perirhinal neurons to familiar compared with novel pictures, and impaired long-term potentiation of synaptic transmission in perirhinal slices. The consistency of these effects across the behavioral, systems, and cellular levels of analysis provides strong evidence for involvement of CREB phosphorylation in synaptic plastic processes within perirhinal cortex necessary for long-term recognition memory.
Original languageEnglish
Pages (from-to)6296-6303
Number of pages8
JournalJournal of Neuroscience
Volume25
Issue number27
DOIs
Publication statusPublished - 6 Jul 2005

Keywords

  • hippocampus
  • familiarity discrimination
  • temporal lobe
  • Fos
  • viral transduction
  • plasticity

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