Callous-unemotional traits and brain structure: Sex-specific effects in anterior insula of typically-developing youths

Nora Maria Raschle, Willeke Martine Menks, Lynn Valérie Fehlbaum, Martin Steppan, Areti Smaragdi, Karen Gonzalez-Madruga, Jack Rogers, Roberta Clanton, Gregor Kohls, Anne Martinelli, Anka Bernhard, Kerstin Konrad, Beate Herpertz-Dahlmann, Christine M. Freitag, Graeme Fairchild, Stephane A. De Brito, Christina Stadler

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Callous-unemotional traits are characterized by a lack of empathy, a disregard for others' feelings and shallow or deficient affect, such as a lack of remorse or guilt. Neuroanatomical correlates of callous-unemotional traits have been demonstrated in clinical samples (i.e., adolescents with disruptive behavior disorders). However, it is unknown whether callous-unemotional traits are associated with neuroanatomical correlates within normative populations without clinical levels of aggression or antisocial behavior. Here we investigated the relationship between callous-unemotional traits and gray matter volume using voxel-based morphometry in a large sample of typically-developing boys and girls (N = 189). Whole-brain multiple regression analyses controlling for site, total intracranial volume, and age were conducted in the whole sample and in boys and girls individually. Results revealed that sex and callous-unemotional traits interacted to predict gray matter volume when considering the whole sample. This interaction was driven by a significant positive correlation between callous-unemotional traits and bilateral anterior insula volume in boys, but not girls. Insula gray matter volume explained 19% of the variance in callous-unemotional traits for boys. Our results demonstrate that callous-unemotional traits are related to variations in brain structure beyond psychiatric samples. This association was observed for boys only, underlining the importance of considering sex as a factor in future research designs. Future longitudinal studies should determine whether these findings hold over childhood and adolescence, and whether the neuroanatomical correlates of callous-unemotional traits are predictive of future psychiatric vulnerability. General scientific summary This study suggests that callous-unemotional traits have a neuroanatomical correlate within typically developing boys, but not girls. Bilateral anterior insula volume explains up to 19% of the variance in callous-unemotional traits in boys.

Original languageEnglish
Pages (from-to)856-864
Number of pages9
JournalNeuroimage Clinical
Volume17
Early online date9 Dec 2017
DOIs
Publication statusPublished - 2018

Keywords

  • Callous-unemotional traits
  • Insula
  • Pediatric neuroimaging
  • Sex differences
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

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  • Cite this

    Raschle, N. M., Menks, W. M., Fehlbaum, L. V., Steppan, M., Smaragdi, A., Gonzalez-Madruga, K., Rogers, J., Clanton, R., Kohls, G., Martinelli, A., Bernhard, A., Konrad, K., Herpertz-Dahlmann, B., Freitag, C. M., Fairchild, G., De Brito, S. A., & Stadler, C. (2018). Callous-unemotional traits and brain structure: Sex-specific effects in anterior insula of typically-developing youths. Neuroimage Clinical, 17, 856-864. https://doi.org/10.1016/j.nicl.2017.12.015