Guaiazulene is an alkyl-substituted azulene available from natural sources and is a much lower cost starting material for the synthesis of azulene derivatives than azulene itself. Here we report an approach for the selective functionalisation of guaiazulene which takes advantage of the acidity of the protons on the guaiazulene C4 methyl group. The aldehyde produced by this approach constitutes a building block for the construction of azulenes substituted on the seven-membered ring. Derivatives of this aldehyde synthesised by alkenylation, reduction and condensation are reported, and the halochromic properties of a subset of these derivatives have been studied.
|Number of pages||10|
|Journal||Organic and Biomolecular Chemistry|
|Early online date||4 Mar 2021|
|Publication status||Published - 21 Mar 2021|
ASJC Scopus subject areas
- Organic Chemistry
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Dual source (Cu and Mo) Single Crystal Diffractometer (SuperNova)Material and Chemical Characterisation (MC2)
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